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Property "Has-20abstract" (as page type) with input value "-5B-5BImage:MITOEAGLE-2Dlogo.jpg-7Cleft-7C100px-7Clink=http:-2F-2Fwww.mitoglobal.org-2Findex.php-2FMITOEAGLE-7CCOST-20Action-20MitoEAGLE-5D-5D-0ACancer-20transformations-20profoundly-20alters-20cellular-20metabolism-20by-20increasing-20glucose-20consumption-20via-20glycolysis-20to-20support-20tumorigenesis.-20Triple-2Dnegative-20breast-20cancer-20(TNBC)-20subtype-20is-20among-20the-20most-20aggressive-20cancers-20with-20the-20worst-20prognosis-20and-20least-20therapeutic-20targetability-20while-20being-20more-20likely-20to-20spread-20and-20recur.-20Here-20we-20confirm-20that-20relative-20to-20ER-2Dpositive-20cells-20(MCF7),-20TNBC-20cells-20(MBA-2DMD-2D231)-20rely-20more-20on-20glycolysis-20thus-20providing-20rationale-20to-20target-20these-20cells-20with-20glycolytic-20inhibitors.-20Indeed,-20iodoacetate-20(IA),-20an-20effective-20GAPDH-20inhibitor,-20caused-20about-2070-25-20drop-20in-20MDA-2DMB-2D231-20cell-20viability-20at-2020-20μM-20while-2040-20μM-20IA-20was-20needed-20to-20decrease-20MCF7-20cell-20viability-20only-20by-2030-25-20within-204-20hours-20of-20treatment.-20However,-20the-20triple-20negative-20cells-20showed-20strong-20ability-20to-20recover-20after-2024-20h-20whereas-20MCF7-20cells-20were-20completely-20eliminated-20at-20concentrations-20-3C-2010-20μM.-20This-20resilient-20TNBC-20cell-20population-20showed-20lower-20apoptotic-20markers,-20moderately-20lowered-20ROS,-20and-20significantly-20greater-20count-20of-20cells-20with-20active-20mitochondria.-20To-20understand-20the-20mechanism-20of-20survival-20we-20studied-20metabolic-20modulations-20associated-20with-20acute-20and-20extended-20treatment-20with-20IA.-20Our-20results-20highlight-20an-20interplay-20between-20PARP-20and-20mitochondrial-20oxidative-20phosphorylation-20in-20TNBC-20that-20comes-20into-20play-20in-20response-20to-20glycolytic-20disruption.-20In-20the-20light-20of-20these-20findings,-20we-20suggest-20that-20combined-20treatment-20with-20PARP-20and-20mitochondrial-20inhibitors-20may-20provide-20novel-20therapeutic-20strategy-20against-20TNBC." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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