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Property "Has-20abstract" (as page type) with input value "-5B-5BImage:MITOEAGLE-2Dlogo.jpg-7Cleft-7C100px-7Clink=http:-2F-2Fwww.mitoglobal.org-2Findex.php-2FMITOEAGLE-7CCOST-20Action-20MitoEAGLE-5D-5D-0ACancers-20of-20various-20types-20consist-20of-20highly-20spanerse-20populations-20of-20cells.-20A-20subset-20of-20cancer-20cells-20with-20stemness-20features,-20cancer-20stem-20cells-20(CSCs),-20are-20believed-20to-20be-20responsible-20for-20tumour-20development-20and-20resistance-20to-20chemotherapy.-20The-20mitochondrial-20metabolism-20of-20CSCs-20has-20been-20shown-20recently-20to-20be-20an-20important-20target-20for-20cancer-20treatment,-20but-20clinical-20significance-20of-20CSCs-20and-20their-20mitochondria-20properties-20remain-20unclear.-20Our-20recent-20study-20provides-20an-20evidence-20that-20adenylate-20kinase-20(AK)-20enzymes-20may-20serve-20as-20specific-20regulators-20of-20metabolic-20remodelling-20in-20CSC-2Dlike-20cells.-20We-20show-20that-20AK-20network-20is-20upregulated-20in-20post-2Doperative-20tissues-20of-20patients-20with-20colon-20cancer-20-5B1-5D.-20AK-20activity-20and-20expression-20level-20were-20increased-20in-20carcinoma-20derived-20CSC-20(2104-20Ep)-20compared-20to-20normal-20embryonic-20stem-20cells-20(H9)-20suggesting-20upregulation-20of-20AK-20as-20a-20distinct-20feature-20of-20malignant-20transformation-20-5B2-5D.-20Interestingly,-20by-20differentiation-20of-20colon-20cancer-20cells-20(Caco-2D2)-20with-20sodium-20butyrate-20we-20were-20able-20to-20re-2Destablish-20AK-20homeostasis.-20Surprisingly,-20the-20availability-20of-20glutamine-20and-20glucose-20in-20cell-20culture-20medium-20was-20able-20to-20alter-20AK-20activity-20upon-20differentiation.-20Induced-20differentiation-20was-20also-20accompanied-20by-20reprogramming-20of-20energy-20metabolism.-20Although-20undifferentiated-20and-20differentiated-20cells-20displayed-20similar-20levels-20of-20ATP,-20differentiated-20cells-20had-20decreased-20levels-20of-20ATP-20produced-20by-20glycolysis-20and-20increased-20levels-20of-20ATP-20derived-20from-20oxidative-20phosphorylation.-20Treated-20cells-20had-20also-20increased-20rates-20of-20cellular-20respiration-20in-20the-20presence-20of-20butyrate-20in-20the-20respiratory-20medium.-20To-20sum-20up,-20our-20study-20introduces-20AK-20as-20a-20potential-20target-20for-20anti-2DCSCs-20therapies-20and-20highlight-20the-20importance-20of-20further-20elucidation-20of-20AK-20role-20in-20metabolic-20reprogramming-20of-20colon-20cancer." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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