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This page provides a simple browsing interface for finding entities described by a property and a named value. Other available search interfaces include the page property search, and the ask query builder.

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Property "Has-20abstract" (as page type) with input value "A-20computational-20model-20for-20the-20mitochondrial-20respiratory-20chain-20that-20appropriately-20balances-20mass,-20charge,-20and-20free-20energy-20transduction-20is-20introduced-20and-20analyzed-20based-20on-20a-20previously-20published-20set-20of-20data-20measured-20on-20isolated-20cardiac-20mitochondria.-20The-20basic-20components-20included-20in-20the-20model-20are-20the-20reactions-20at-20Complexes-20I,-20III,-20and-20IV-20of-20the-20electron-20transport-20system,-20ATP-20synthesis-20at-20F1FO-20ATPase,-20substrate-20transporters-20including-20adenine-20nucleotide-20translocase-20and-20the-20phosphate-2Dhydrogen-20co-2Dtransporter,-20and-20cation-20fluxes-20across-20the-20inner-20membrane-20including-20fluxes-20through-20the-20K-3Csup-3E+-3C-2Fsup-3E-2FH-3Csup-3E+-3C-2Fsup-3E-20antiporter-20and-20passive-20H-3Csup-3E+-3C-2Fsup-3E-20and-20K-3Csup-3E+-3C-2Fsup-3E-20permeation.-20Estimation-20of-2016-20adjustable-20parameter-20values-20is-20based-20on-20fitting-20model-20simulations-20to-20nine-20independent-20data-20curves.-20The-20identified-20model-20is-20further-20validated-20by-20comparison-20to-20additional-20datasets-20measured-20from-20mitochondria-20isolated-20from-20rat-20heart-20and-20liver-20and-20observed-20at-20low-20oxygen-20concentration.-20To-20obtain-20reasonable-20fits-20to-20the-20available-20data,-20it-20is-20necessary-20to-20incorporate-20inorganic-2Dphosphate-2Ddependent-20activation-20of-20the-20dehydrogenase-20activity-20and-20the-20electron-20transport-20system.-20Specifically,-20it-20is-20shown-20that-20a-20model-20incorporating-20phosphate-2Ddependent-20activation-20of-20Complex-20III-20is-20able-20to-20reasonably-20reproduce-20the-20observed-20data.-20The-20resulting-20validated-20and-20verified-20model-20provides-20a-20foundation-20for-20building-20larger-20and-20more-20complex-20systems-20models-20and-20investigating-20complex-20physiological-20and-20pathophysiological-20interactions-20in-20cardiac-20energetics." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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