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Property "Has-20abstract" (as page type) with input value "Accumulating-20evidence-20indicates-20that-20the-20MDM2-20oncoprotein-20promotes-20tumorigenesis-20beyond-20its-20canonical-20negative-20effects-20on-20the-20p53-20tumor-20suppressor,-20but-20these-20p53-2Dindependent-20functions-20remain-20poorly-20understood.-20Here,-20we-20show-20that-20a-20fraction-20of-20endogenous-20MDM2-20is-20actively-20imported-20in-20mitochondria-20to-20control-20respiration-20and-20mitochondrial-20dynamics-20independently-20of-20p53.-20Mitochondrial-20MDM2-20represses-20the-20transcription-20of-20NADH-2Ddehydrogenase-206-20(MT-2DND6)-20-27-27in-20vitro-27-27-20and-20-27-27in-20vivo-27-27,-20impinging-20on-20respiratory-20complex-20I-20activity-20and-20enhancing-20mitochondrial-20ROS-20production.-20Recruitment-20of-20MDM2-20to-20mitochondria-20increases-20during-20oxidative-20stress-20and-20hypoxia.-20Accordingly,-20mice-20lacking-20MDM2-20in-20skeletal-20muscles-20exhibit-20higher-20MT-2DND6-20levels,-20enhanced-20complex-20I-20activity,-20and-20increased-20muscular-20endurance-20in-20mild-20hypoxic-20conditions.-20Furthermore,-20increased-20mitochondrial-20MDM2-20levels-20enhance-20the-20migratory-20and-20invasive-20properties-20of-20cancer-20cells.-20Collectively,-20these-20data-20uncover-20a-20previously-20unsuspected-20function-20of-20the-20MDM2-20oncoprotein-20in-20mitochondria-20that-20play-20critical-20roles-20in-20skeletal-20muscle-20physiology-20and-20may-20contribute-20to-20tumor-20progression." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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