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Property "Has-20abstract" (as page type) with input value "Alterations-20in-20lipid-20metabolism-20within-20the-20heart-20may-20have-20a-20causal-20role-20in-20the-20establishment-20of-20diabetic-20cardiomyopathy,-20however-20this-20remains-20equivocal.-20Therefore,-20in-20the-20current-20study-20we-20determined-20cardiac-20mitochondrial-20bioenergetics-20in-20ZDF-20rats-20before-20overt-20type-202-20diabetes-20and-20diabetic-20cardiomyopathy-20developed.-20In-20addition,-20we-20utilized-20resveratrol,-20a-20compound-20previously-20shown-20to-20improve-20prevent-20or-20reverse-20cardiac-20dysfunction-20in-20high-20fat-2Dfed-20rodents,-20as-20a-20tool-20to-20potential-20recover-20dysfunctions-20within-20mitochondria.-20Fasting-20blood-20glucose-20and-20invasive-20left-20ventricular-20hemodynamic-20analysis-20confirmed-20the-20absence-20of-20type-202-20diabetes-20and-20diabetic-20cardiomyopathy.-20However,-20fibrosis-20was-20already-20increased-20(P-3C0.05)-20~70-25-20in-20ZDF-20rats-20at-20this-20early-20stage-20in-20disease-20progression.-20Assessments-20of-20mitochondrial-20ADP-20and-20pyruvate-20respiratory-20kinetics-20in-20permeabilized-20fibres-20from-20the-20left-20ventricle-20revealed-20normal-20electron-20transport-20chain-20function-20and-20content.-20In-20contrast,-20the-20apparent-20Km-20to-20palmitoyl-2DCoA-20(P-2DCoA)-20was-20increased-20(P-3C0.05)-20~60-25,-20which-20was-20associated-20with-20an-20accumulation-20of-20intracellular-20triacylgycerol,-20diacylglycerol-20and-20ceramide-20species.-20In-20addition,-20the-20capacity-20for-20mitochondrial-20ROS-20emission-20was-20increased-20(P-3C0.05)-20~3-2Dfold-20in-20ZDF-20rats.-20The-20provision-20of-20resveratrol-20recovered-20fibrosis,-20P-2DCoA-20respiratory-20sensitivity,-20reactive-20lipid-20accumulation-20and-20mitochondrial-20reactive-20oxygen-20species-20emission-20rates.-20Altogether-20the-20current-20data-20supports-20the-20supposition-20that-20a-20chronic-20dysfunction-20within-20mitochondrial-20lipid-2Dsupported-20bioenergetics-20contributes-20to-20the-20development-20of-20diabetic-20cardiomyopathy,-20as-20this-20was-20present-20before-20overt-20diabetes-20or-20cardiac-20dysfunction.-20In-20addition,-20we-20show-20resveratrol-20supplementation-20prevents-20these-20changes,-20supporting-20the-20belief-20that-20resveratrol-20is-20a-20potent-20therapeutic-20approach-20for-20preventing-20diabetic-20cardiomyopathy." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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