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Property "Has-20abstract" (as page type) with input value "At-20the-20annual-20Iditarod-20Race,-20Alaskan-20Huskies-20repeatedly-20run-20for-20up-20to-208-20hours-20at-2016-20km-2Fh-20to-20complete-201600-20km.-20We-20previously-20demonstrated-20high-20rates-20of-20mitochondrial-20protein-20synthesis-20in-20Alaskan-20Huskies,-20which-20we-20suspected-20allowed-20rapid-20remodeling-20of-20mitochondrial-20proteins-20in-20response-20to-20energetic-20stress.-20The-20purpose-20of-20this-20study-20was-20to-20examine-20mitochondrial-20respiration-20in-20permeabilized-20skeletal-20muscle-20fibers-20of-20Alaskan-20Huskies-20in-20the-20offseason-20(Non-2Draced)-20and-20following-20the-201600-20km-20Iditarod-20Sled-20Dog-20Race-20(Raced).-20We-20hypothesized-20that-20compared-20to-20Non-2Draced-20Huskies,-20raced-20Huskies-20that-20completed-20a-201600-20km-20race-20would-20have-20greater-20mitochondrial-20respiratory-20capacities,-20and-20improvements-20in-20capacities-20of-20oxidative-20phosphorylation-20(OXPHOS)-20based-20on-20NADH-2Dgenerating-20substrates-20as-20compared-20to-20fatty-20acids.-20Using-20high-2Dresolution-20respirometry-20(HRR)-20we-20investigated-20the-20respiration-20of-20permeabilized-20muscle-20fibers-20from-20Alaskan-20Huskies.-20Maximum-20capacities-20were-20254±26-20pmol.s-3Csup-3E-2D1-3C-2Fsup-3E.mg-3Csup-3E-2D1-3C-2Fsup-3E-20for-20OXPHOS-20(coupled,-20P)-20and-20254±37-20pmol.s-3Csup-3E-2D1-3C-2Fsup-3E.mg-3Csup-3E-2D1-3C-2Fsup-3E-20for-20the-20electron-20transfer-2Dpathway-20(ET-2Dpathway-3B-20non-2Dcoupled,-20E).-20After-20racing-20respiratory-20capacities-20from-20NADH-2Dlinked-20substrates,-20but-20not-20fat-2Dderived-20substrates-20increased.-20Finally,-20the-20OXPHOS-20to-20ET-20capacity-20ratio-20(P-2FE)-20increased-20after-20racing-20from-200.90±0.03-20to-200.97±0.02.-20From-20our-20previous-20studies-20and-20the-20current-20study,-20we-20conclude-20that-20Alaskan-20Huskies-20maintain-20high-20mitochondrial-20protein-20turnover-20to-20facilitate-20rapid-20adaptation-20to-20environmental-20extremes-20and-20energetic-20challenges." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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