Search by property

Property "Has-20abstract" (as page type) with input value "Both-20human-20and-20animal-20studies-20have-20shown-20mitochondrial-20and-20contractile-20dysfunction-20in-20hearts-20of-20type-202-20diabetes-20mellitus-20(T2DM).-20Exercise-20training-20has-20shown-20positive-20effects-20on-20cardiac-20function,-20but-20its-20effect-20on-20the-20mitochondria-20have-20been-20insufficiently-20explored.-20The-20aim-20of-20this-20study-20was-20to-20assess-20the-20effect-20of-20exercise-20training-20on-20mitochondrial-20function-20in-20T2DM-20hearts.-20We-20spanided-20T2DM-20mice-20(db-2Fdb)-20into-20a-20sedentary-20and-20an-20interval-20training-20group-20at-208-20weeks-20of-20age-20and-20used-20heterozygote-20db-2F+-20as-20controls.-20After-208-20weeks-20of-20training,-20we-20evaluated-20mitochondrial-20structure-20and-20function,-20as-20well-20as-20the-20levels-20of-20mRNA-20and-20proteins-20involved-20in-20key-20metabolic-20processes-20from-20the-20left-20ventricle.-20db-2Fdb-20animals-20showed-20decreased-20oxidative-20phosphorylation-20capacity-20and-20fragmented-20mitochondria.-20Mitochondrial-20respiration-20showed-20a-20blunted-20response-20to-20Ca-3Csup-3E2+-3C-2Fsup-3E-20along-20with-20reduced-20protein-20levels-20of-20the-20mitochondrial-20calcium-20uniporter.-20Exercise-20training-20ameliorated-20the-20reduced-20oxidative-20phosphorylation-20in-20complex-20(C)-20I + II,-20CII-20and-20CIV,-20but-20not-20CI-20or-20Ca-3Csup-3E2+-3C-2Fsup-3E-20response.-20Mitochondrial-20fragmentation-20was-20partially-20restored.-20mRNA-20levels-20of-20isocitrate,-20succinate-20and-20oxoglutarate-20dehydrogenase-20were-20increased-20in-20db-2Fdb-20mice-20and-20normalized-20by-20exercise-20training.-20Exercise-20training-20induced-20an-20upregulation-20of-20two-20transcripts-20of-20peroxisome-20proliferator-20activated-20receptor-20gamma-20coactivator-201-20alpha-20(PGC1α1-20and-20PGC1α4)-20previously-20linked-20to-20endurance-20training-20adaptations-20and-20strength-20training-20adaptations,-20respectively.-20The-20T2DM-20heart-20showed-20mitochondrial-20dysfunction-20at-20multiple-20levels-20and-20exercise-20training-20ameliorated-20some,-20but-20not-20all-20mitochondrial-20dysfunctions." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

Showing below up to 0 results starting with #1.

View (previous 50 | next 50) (20 | 50 | 100 | 250 | 500)