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This page provides a simple browsing interface for finding entities described by a property and a named value. Other available search interfaces include the page property search, and the ask query builder.

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Property "Has-20abstract" (as page type) with input value "Caloric-20restriction-20(CR)-20promotes-20lifespan-20extension-20and-20protects-20against-20many-20pathological-20conditions,-20including-20ischemia-2Freperfusion-20injury-20to-20the-20brain,-20heart-20and-20kidney.-20In-20the-20liver,-20ischemia-2Freperfusion-20damage-20is-20related-20to-20excessive-20mitochondrial-20Ca-3Csup-3E2+-3C-2Fsup-3E-20accumulation,-20leading-20to-20the-20mitochondrial-20permeability-20transition.-20Indeed,-20liver-20mitochondria-20isolated-20from-20animals-20maintained-20on-20CR-20for-204-20months-20were-20protected-20against-20permeability-20transition-20and-20capable-20of-20taking-20up-20Ca-3Csup-3E2+-3C-2Fsup-3E-20at-20faster-20rates-20and-20in-20larger-20quantities.-20These-20changes-20were-20not-20related-20to-20modifications-20in-20mitochondrial-20respiratory-20activity,-20but-20rather-20to-20a-20higher-20proportion-20of-20ATP-20relative-20to-20ADP-20in-20CR-20liver-20mitochondria.-20Accordingly,-20both-20depletion-20of-20mitochondrial-20adenine-20nucleotides-20and-20loading-20mitochondria-20with-20exogenous-20ATP-20abolished-20the-20differences-20between-20CR-20and-20ad-20libitum-20(AL)-20fed-20groups.-20The-20prevention-20against-20permeability-20transition-20promoted-20by-20CR-20strongly-20protected-20against-20-27-27in-20vivo-27-27-20liver-20damage-20induced-20by-20ischemia-2Freperfusion.-20Overall,-20our-20results-20show-20that-20CR-20strongly-20protects-20the-20liver-20against-20ischemia-2Freperfusion-20and-20uncover-20a-20mechanism-20for-20this-20protection,-20through-20a-20yet-20undescribed-20diet-2Dinduced-20change-20in-20liver-20mitochondrial-20Ca-3Csup-3E2+-3C-2Fsup-3E-20handling-20related-20to-20elevated-20intramitochondrial-20ATP.-0A-0ACopyright-20©-202017-20Elsevier-20Inc.-20All-20rights-20reserved." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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