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Property "Has-20abstract" (as page type) with input value "Cancer-20cells-20without-20mitochondrial-20DNA-20(mtDNA)-20do-20not-20form-20tumors-20unless-20they-20reconstitute-20oxidative-20phosphorylation-20(OXPHOS)-20by-20mitochondria-20acquired-20from-20host-20stroma.-20To-20understand-20why-20functional-20respiration-20is-20crucial-20for-20tumorigenesis,-20we-20used-20time-2Dresolved-20analysis-20of-20tumor-20formation-20by-20mtDNA-2Ddepleted-20cells-20and-20genetic-20manipulations-20of-20OXPHOS.-20We-20show-20that-20pyrimidine-20biosynthesis-20dependent-20on-20respiration-2Dlinked-20dihydroorotate-20dehydrogenase-20(DHODH)-20is-20required-20to-20overcome-20cell-2Dcycle-20arrest,-20while-20mitochondrial-20ATP-20generation-20is-20dispensable-20for-20tumorigenesis.-20Latent-20DHODH-20in-20mtDNA-2Ddeficient-20cells-20is-20fully-20activated-20with-20restoration-20of-20complex-20III-2FIV-20activity-20and-20coenzyme-20Q-20redox-2Dcycling-20after-20mitochondrial-20transfer,-20or-20by-20introduction-20of-20an-20alternative-20oxidase.-20Further,-20deletion-20of-20DHODH-20interferes-20with-20tumor-20formation-20in-20cells-20with-20fully-20functional-20OXPHOS,-20while-20disruption-20of-20mitochondrial-20ATP-20synthase-20has-20little-20effect.-20Our-20results-20show-20that-20DHODH-2Ddriven-20pyrimidine-20biosynthesis-20is-20an-20essential-20pathway-20linking-20respiration-20to-20tumorigenesis,-20pointing-20to-20inhibitors-20of-20DHODH-20as-20potential-20anti-2Dcancer-20agents." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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