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Property "Has-20abstract" (as page type) with input value "Catching-20primal-20functional-20changes-20in-20early,-20'very-20far-20from-20disease-20onset'-20(VFDO)-20stages-20of-20Huntington's-20disease-20is-20likely-20to-20be-20the-20key-20to-20a-20successful-20therapy.-20Focusing-20on-20VFDO-20stages,-20we-20assessed-20neuronal-20microcircuits-20in-20premanifest-20Hdh150-20knock-2Din-20mice.-20Employing-20-27-27in-20vivo-27-27-20two-2Dphoton-20Ca-3Csup-3E2+-3C-2Fsup-3E-20imaging,-20we-20revealed-20an-20early-20pattern-20of-20circuit-20dysregulation-20in-20the-20visual-20cortex-20-2D-20one-20of-20the-20first-20regions-20affected-20in-20premanifest-20Huntington's-20disease-20-2D-20characterized-20by-20an-20increase-20in-20activity,-20an-20enhanced-20synchronicity-20and-20hyperactive-20neurons.-20These-20findings-20are-20accompanied-20by-20aberrations-20in-20animal-20behavior.-20We-20furthermore-20show-20that-20the-20antidiabetic-20drug-20metformin-20diminishes-20aberrant-20Huntingtin-20protein-20load-20and-20fully-20restores-20both-20early-20network-20activity-20patterns-20and-20behavioral-20aberrations.-20This-20network-2Dcentered-20approach-20reveals-20a-20critical-20window-20of-20vulnerability-20far-20before-20clinical-20manifestation-20and-20establishes-20metformin-20as-20a-20promising-20candidate-20for-20a-20chronic-20therapy-20starting-20early-20in-20premanifest-20Huntington's-20disease-20pathogenesis-20long-20before-20the-20onset-20of-20clinical-20symptoms." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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