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Property "Has-20abstract" (as page type) with input value "Dementia-20contributes-20substantially-20to-20the-20burden-20of-20disability-20experienced-20at-20old-20age,-20and-20mitochondrial-20dysfunction-20(MD)-20was-20identified-20as-20common-20final-20pathway-20in-20brain-20aging-20and-20Alzheimer's-20disease.-20Due-20to-20its-20early-20appearance,-20MD-20is-20a-20promising-20target-20for-20nutritional-20prevention-20strategies-20and-20polyphenols-20as-20potential-20neurohormetic-20inducers-20may-20be-20strong-20neuroprotective-20candidates.-20This-20study-20aimed-20to-20investigate-20the-20effects-20of-20a-20polyphenol-2Drich-20grape-20skin-20extract-20(PGE)-20on-20age-2Drelated-20dysfunctions-20of-20brain-20mitochondria,-20memory,-20life-20span-20and-20potential-20hormetic-20pathways-20in-20C57BL-2F6J-20mice.-20PGE-20was-20administered-20at-20a-20dose-20of-20200-20mg-2Fkg-20body-20weight-2Fd-20in-20a-203-2Dweek-20short-2Dterm,-206-2Dmonth-20long-2Dterm-20and-20life-2Dlong-20study.-20MD-20in-20the-20brains-20of-20aged-20mice-20(19-2D22-20months-20old)-20compared-20to-20young-20mice-20(3-20months-20old)-20was-20demonstrated-20by-20lower-20ATP-20levels-20and-20by-20impaired-20mitochondrial-20respiratory-20complex-20activity-20(except-20for-20mice-20treated-20with-20antioxidant-2Ddepleted-20food-20pellets).-20Long-2Dterm-20PGE-20feeding-20partly-20enhanced-20brain-20mitochondrial-20respiration-20with-20only-20minor-20beneficial-20effect-20on-20brain-20ATP-20levels-20and-20memory-20of-20aged-20mice.-20Life-2Dlong-20PGE-20feeding-20led-20to-20a-20transient-20but-20significant-20shift-20of-20survival-20curve-20toward-20higher-20survival-20rates-20but-20without-20effect-20on-20the-20overall-20survival.-20The-20moderate-20effects-20of-20PGE-20were-20associated-20with-20elevated-20SIRT1-20but-20not-20SIRT3-20mRNA-20expressions-20in-20brain-20and-20liver-20tissue.-20The-20beneficial-20effects-20of-20the-20grape-20extract-20may-20have-20been-20influenced-20by-20the-20profile-20of-20bioavailable-20polyphenols-20and-20the-20starting-20point-20of-20interventions." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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