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This page provides a simple browsing interface for finding entities described by a property and a named value. Other available search interfaces include the page property search, and the ask query builder.

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Property "Has-20abstract" (as page type) with input value "Endothelial-20cells-20in-20the-20vascular-20system-20are-20constantly-20subjected-20to-20the-20frictional-20force-20of-20shear-20stress-20due-20to-20the-20pulsatile-20nature-20of-20blood-20flow.-20Although-20several-20proteins-20form-20part-20of-20the-20shear-20stress-20mechano-2Dsensing-20pathway,-20the-20identification-20of-20mechano-2Dtransducing-20pathways-20is-20largely-20unknown.-20Given-20the-20increasing-20evidence-20for-20a-20signaling-20function-20of-20mitochondria-20in-20endothelial-20cells,-20the-20aim-20of-20this-20study-20was-20to-20investigate-20their-20role-20as-20mechano-2Dsensor-20organelles-20during-20laminar-20shear-20stress-20(LSS).-20We-20demonstrated-20that-20LSS-20activates-20intracellular-20signaling-20pathways-20that-20modulate-20not-20only-20mitochondrial-20dynamics-20but-20also-20mitochondrial-20function.-20At-20early-20time-20points-20of-20LSS,-20the-20fission-2Drelated-20protein-20Drp1-20was-20recruited-20from-20the-20cytosol-20to-20mitochondria-20and-20activated-20mitochondrial-20fission.-20LSS-2Ddependent-20increase-20in-20intracellular-20Ca2+-20concentration-20was-20indispensable-20for-20mitochondrial-20fission.-20As-20alterations-20in-20mitochondrial-20dynamics-20have-20been-20related-20to-20changes-20in-20bioenergetics-20profiles,-20we-20studied-20mitochondrial-20function-20after-20LSS.-20We-20found-20that-20LSS-20decreased-20respiration-20rate,-20increased-20mitochondrial-20membrane-20potential-20and-20promoted-20the-20mitochondrial-20generation-20of-20ROS-20with-20the-20subsequent-20oxidation-20and-20activation-20of-20the-20antioxidant-20enzyme-20PRX3.-20Our-20data-20support-20a-20novel-20and-20active-20role-20for-20mitochondria-20in-20endothelial-20cells-20as-20active-20players,-20able-20to-20transduce-20the-20mechanical-20force-20of-20shear-20stress-20in-20the-20vascular-20endothelium-20into-20a-20biological-20response." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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