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This page provides a simple browsing interface for finding entities described by a property and a named value. Other available search interfaces include the page property search, and the ask query builder.

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Property "Has-20abstract" (as page type) with input value "Given-20the-20association-20between-20high-20aerobic-20capacity-20and-20the-20prevention-20of-20metabolic-20diseases,-20elucidating-20the-20mechanisms-20by-20which-20high-20aerobic-20capacity-20regulates-20whole-2Dbody-20metabolic-20homeostasis-20is-20a-20major-20research-20challenge.-20Oxidative-20post-2Dtranslational-20modifications-20(Ox-2DPTMs)-20of-20proteins-20can-20regulate-20cellular-20homeostasis-20in-20skeletal-20and-20cardiac-20muscles,-20but-20the-20relationship-20between-20Ox-2DPTMs-20and-20intrinsic-20components-20of-20oxidative-20energy-20metabolism-20is-20still-20unclear.-20Here,-20we-20evaluated-20the-20Ox-2DPTM-20profile-20in-20cardiac-20and-20skeletal-20muscles-20of-20rats-20bred-20for-20low-20(LCR)-20and-20high-20(HCR)-20intrinsic-20aerobic-20capacity.-20Redox-20proteomics-20screening-20revealed-20different-20cysteine-20(Cys)-20Ox-2DPTM-20profile-20between-20HCR-20and-20LCR-20rats.-20HCR-20showed-20a-20higher-20number-20of-20oxidized-20Cys-20residues-20in-20skeletal-20muscle-20compared-20to-20LCR,-20while-20the-20opposite-20was-20observed-20in-20the-20heart.-20Most-20proteins-20with-20differentially-20oxidized-20Cys-20residues-20in-20the-20skeletal-20muscle-20are-20important-20regulators-20of-20oxidative-20metabolism.-20The-20most-20oxidized-20protein-20in-20the-20skeletal-20muscle-20of-20HCR-20rats-20was-20malate-20dehydrogenase-20(MDH1).-20HCR-20showed-20higher-20MDH1-20activity-20compared-20to-20LCR-20in-20skeletal,-20but-20not-20cardiac-20muscle.-20These-20novel-20findings-20indicate-20a-20clear-20association-20between-20Cys-20Ox-2DPTMs-20and-20aerobic-20capacity,-20leading-20to-20novel-20insights-20into-20the-20role-20of-20Ox-2DPTMs-20as-20an-20essential-20signal-20to-20maintain-20metabolic-20homeostasis." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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