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Property "Has-20abstract" (as page type) with input value "HIF-20prolyl-20hydroxylases-20(PHD1-2D3)-20are-20oxygen-20sensors-20that-20regulate-20the-20stability-20of-20the-20hypoxia-2Dinducible-20factors-20(HIFs)-20in-20an-20oxygen-2Ddependent-20manner.-20Here,-20we-20show-20that-20loss-20of-20Phd1-20lowers-20oxygen-20consumption-20in-20skeletal-20muscle-20by-20reprogramming-20glucose-20metabolism-20from-20oxidative-20to-20more-20anaerobic-20ATP-20production-20through-20activation-20of-20a-20Pparα-20pathway.-20This-20metabolic-20adaptation-20to-20oxygen-20conservation-20impairs-20oxidative-20muscle-20performance-20in-20healthy-20conditions,-20but-20it-20provides-20acute-20protection-20of-20myofibers-20against-20lethal-20ischemia.-20Hypoxia-20tolerance-20is-20not-20due-20to-20HIF-2Ddependent-20angiogenesis,-20erythropoiesis-20or-20vasodilation,-20but-20rather-20to-20reduced-20generation-20of-20oxidative-20stress,-20which-20allows-20Phd1-2Ddeficient-20myofibers-20to-20preserve-20mitochondrial-20respiration.-20Hypoxia-20tolerance-20relies-20primarily-20on-20Hif-2D2α-20and-20was-20not-20observed-20in-20heterozygous-20Phd2-2Ddeficient-20or-20homozygous-20Phd3-2Ddeficient-20mice.-20Of-20medical-20importance,-20conditional-20knockdown-20of-20Phd1-20also-20rapidly-20induces-20hypoxia-20tolerance.-20These-20findings-20delineate-20a-20new-20role-20of-20Phd1-20in-20hypoxia-20tolerance-20and-20offer-20new-20treatment-20perspectives-20for-20disorders-20characterized-20by-20oxidative-20stress." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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