Search by property

Property "Has-20abstract" (as page type) with input value "Heart-20failure-20is-20a-20multifaceted-20disease-20involving-20both-20energetic-20and-20mechanical-20deficits.-20In-20order-20to-20help-20the-20heart-20mechanically,-20a-20left-20ventricular-20assist-20device-20(LVAD)-20is-20often-20employed-20in-20heart-20failure-20patients.-20This-20device-20unloads-20the-20heart-20and-20patients-20usually-20see-20improvements-20in-20several-20functional-20parameters.-20In-20this-20study,-20the-20cardiac-20mitochondrial-20function-20of-20two-20pediatric-20patients-20with-20LVADs-20was-20assessed-20before-20insertion-20of-20the-20LVAD-20and-20then-20in-20the-20explanted-20heart-20after-20the-20patients-20received-20a-20heart-20transplant.-20-0A-0AA-20small-20piece-20of-20LV-20tissue-20was-20recovered-20at-20the-20time-20of-20LVAD-20implantation-20for-20both-20patients.-20Later,-20when-20these-20patients-20received-20a-20transplant,-20a-20sample-20from-20the-20explanted-20heart-20was-20used-20for-20this-20study.-20In-20both-20instances,-20heart-20tissue-20was-20rapidly-20harvested-20in-20the-20operating-20room,-20placed-20in-20BIOPS-20solution,-20kept-20at-204°C,-20and-20mitochondrial-20respirometry-20by-20Oroboros-20Oxygraph-2D2k-20was-20performed.-0A-0AIn-20the-20first-20patient,-20a-2014.3-20year-20old-20female-20with-20an-20LVAD-20for-207-20days,-20O2k-20respirometry-20in-20BIOPS-20preserved-20tissue-20fibers-20showed-20a-20trend-20for-20increased-20respiratory-20control-20ratio-20(-27-27p-27-27=0.07),-20but-20no-20improvements-20in-20the-20other-20measured-20parameters-20using-20pyruvate-2Fmalate,-20glutamate-20or-20succinate-20as-20substrates.-20In-20contrast,-20the-20second-20patient,-20a-2016-20year-20old-20female,-20had-20her-20LVAD-20for-2045-20days-20and-20did-20show-20significant-20improvements-20in-20respiration-20rate-20with-20pyruvate-2Fmalate-20as-20well-20as-20glutamate.-20Respiration-20with-20succinate-20and-20the-20respiratory-20control-20ratio-20in-20the-20second-20patient-20also-20showed-20a-20trend-20for-20increase-20(both-20-27-27p-27-27=0.06)-20with-20the-20LVAD.-0A-0AIn-20summary,-20mitochondrial-20function-20can-20be-20measured-20in-20small-20pieces-20of-20heart-20tissue-20extracted-20during-20LVAD-20implantation.-20Although-20the-20LVAD-20is-20a-20mechanical-20device,-20its-20implantation-20results-20in-20an-20energetic-20improvement-20with-20a-20positive-20effect-20on-20mitochondrial-20function.-20This-20mitochondrial-20improvement,-20however,-20seems-20to-20take-20longer-20than-20a-20week-20to-20occur-20in-20a-20measurable-20manner." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

Showing below up to 0 results starting with #1.

View (previous 50 | next 50) (20 | 50 | 100 | 250 | 500)