Cookies help us deliver our services. By using our services, you agree to our use of cookies. More information

Search by property

From Bioblast

This page provides a simple browsing interface for finding entities described by a property and a named value. Other available search interfaces include the page property search, and the ask query builder.

Search by property

Property "Has-20abstract" (as page type) with input value "Heart-20failure-20is-20associated-20with-20altered-20myocardial-20substrate-20metabolism-20and-20impaired-20cardiac-20energetics.-20Comorbidities-20like-20diabetes-20may-20influence-20the-20metabolic-20adaptations-20during-20heart-20failure-20development.-20We-20quantified-20to-20what-20extent-20changes-20in-20substrate-20preference,-20lipid-20accumulation,-20and-20energy-20status-20predict-20the-20longitudinal-20development-20of-20hypertrophy-20and-20failure-20in-20the-20non-2Ddiabetic-20and-20the-20diabetic-20heart.-0A-0ATransverse-20aortic-20constriction-20(TAC)-20was-20performed-20in-20non-2Ddiabetic-20(-27-27db-27-27-2F+)-20and-20diabetic-20(-27-27db-27-27-2F-27-27db-27-27)-20mice-20to-20induce-20pressure-20overload.-20Magnetic-20resonance-20imaging,-20-3Csup-3E31-3C-2Fsup-3EP-20magnetic-20resonance-20spectroscopy-20(MRS),-20-3Csup-3E1-3C-2Fsup-3EH-20MRS,-20and-20-3Csup-3E18-3C-2Fsup-3EF-2Dfluorodeoxyglucose-2Dpositron-20emission-20tomography-20(PET)-20were-20applied-20to-20measure-20cardiac-20function,-20energy-20status,-20lipid-20content,-20and-20glucose-20uptake,-20respectively.-20-27-27In-20vivo-27-27-20measurements-20were-20complemented-20with-20-27-27ex-20vivo-27-27-20techniques-20of-20high-2Dresolution-20respirometry,-20proteomics,-20and-20western-20blotting-20to-20elucidate-20the-20underlying-20molecular-20pathways.-20In-20non-2Ddiabetic-20mice,-20TAC-20induced-20progressive-20cardiac-20hypertrophy-20and-20dysfunction,-20which-20correlated-20with-20increased-20protein-20kinase-20D-2D1-20(PKD1)-20phosphorylation-20and-20increased-20glucose-20uptake.-20These-20changes-20in-20glucose-20utilization-20preceded-20a-20reduction-20in-20cardiac-20energy-20status.-20At-20baseline,-20compared-20with-20non-2Ddiabetic-20mice,-20diabetic-20mice-20showed-20normal-20cardiac-20function,-20higher-20lipid-20content-20and-20mitochondrial-20capacity-20for-20fatty-20acid-20oxidation,-20and-20lower-20PKD1-20phosphorylation,-20glucose-20uptake,-20and-20energetics.-20Interestingly,-20TAC-20affected-20cardiac-20function-20only-20mildly-20in-20diabetic-20mice,-20which-20was-20accompanied-20by-20normalization-20of-20phosphorylated-20PKD1,-20glucose-20uptake,-20and-20cardiac-20energy-20status.-0A-0AThe-20cardiac-20metabolic-20adaptations-20in-20diabetic-20mice-20seem-20to-20prevent-20the-20heart-20from-20failing-20upon-20pressure-20overload,-20suggesting-20that-20restoring-20the-20balance-20between-20glucose-20and-20fatty-20acid-20utilization-20is-20beneficial-20for-20cardiac-20function." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

Showing below up to 0 results starting with #1.

View (previous 50 | next 50) (20 | 50 | 100 | 250 | 500)


    

List of results

No results.