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Property "Has-20abstract" (as page type) with input value "Human-20Chronic-20Lymphocytic-20Leukemia-20(B-2DCLL)-20is-20the-20most-20commonly-20diagnosed-20leukemia-20in-20the-20western-20world.-20Therapeutic-20options-20to-20treat-20this-20leukemia-20are-20very-20limited.-20B-2DCLL-20is-20characterized-20by-20a-20clonal-20accumulation-20of-20mature-20neoplastic-20B-20cells-20that-20are-20resistant-20to-20apoptosis.-20Different-20leukemic-20cells-20or-20cell-20lines,-20both-20myeloid-20and-20lymphoid,-20express-2Foverexpress-20several-20potassium-20channels-20including-20shaker-20type-20voltage-2Dgated-20Kv1.3,-20Kv11.1-20(Herg),-20and-20calcium-2Dactivated-20KCa3.1,-20and-20their-20pharmacological-20inhibition-20has-20been-20related-20to-20reduced-20B-2DCLL-20proliferation,-20pointing-20to-20ion-20channels-20as-20promising-20oncological-20targets-20in-20B-2DCLL.-20We-20obtained-20evidence-20that-20Kv1.3-20is-20highly-20expressed-20in-20B-2DCLL-20respect-20to-20normal-20B-20cells-20both-20in-20the-20plasma-20membrane-20and-20in-20the-20inner-20mitochondrial-20membrane.-20We-20have-20recently-20shown-20that-20the-20treatment-20with-20mitochondrial-20Kv1.3-20inhibitors-20actively-20killed-20primary-20B-2DCLL-20cells-20in-20-27-27ex-2Dvivo-27-27-20experiments,-20by-20induction-20of-20intrinsic-20apoptosis.-20Importantly,-20cells-20form-20healthy-20subjects-20and-20even-20residual-20normal-20T-20lymphocytes-20of-20the-20same-20patients-20were-20unaffected-20by-20the-20drugs,-20while-20B-2DCLL-20cells-20were-20killed.-20Importantly,-20B-2DCLL-20cell-20death-20was-20observed-20also-20when-20leukemic-20cells-20were-20co-2Dcultured-20with-20mesenchymal-20stromal-20cells-20(MSC),-20which-20favor-20tumor-20cell-20growth-20by-20releasing-20anti-2Dapoptotic-20and-20pro-2Dsurvival-20factors.-20Here-20we-20report-20the-20first-20-27-27in-20vivo-27-27-20evidence,-20that-20pharmacological-20targeting-20of-20the-20mitochondrial-20Kv1.3-20by-20a-20new-20mitochondrial-20targeted-20inhibitor-20is-20sufficient-20to-20lead-20to-20a-20massive-20CD5+-2FCD19+-20elimination-20in-20several-20organs-20(blood,-20peritoneal-20cavity,-20spleen,-20bone-20marrow)-20in-20a-20B-2DCLL-20genetic-20mouse-20model-20(EuTCL-2D1),-20without-20inducing-20side-20effects-20and-20death-20in-20healthy-20immune-20cells,-20including-20cytotoxic-20T-20lymphocytes.-20These-20results-20open-20the-20possibility-20to-20a-20new-20therapeutical-20approach-20for-20this-20disease-20by-20directly-20targeting-20the-20mitochondrial-20channel." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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