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Property "Has-20abstract" (as page type) with input value "Impaired-20mitochondrial-20function-20and-20accumulation-20of-20DNA-20damage-20have-20been-20recognized-20as-20hallmarks-20of-20age-2Drelated-20diseases.-20Mitochondrial-20dysfunction-20initiates-20protective-20signalling-20mechanisms-20coordinated-20at-20nuclear-20level-20particularly-20by-20modulating-20transcription-20of-20stress-20signalling-20factors.-20In-20turn,-20cellular-20response-20to-20DNA-20lesions-20comprises-20a-20series-20of-20interconnected-20complex-20protective-20pathways,-20which-20require-20the-20energetic-20and-20metabolic-20support-20of-20the-20mitochondria.-20These-20are-20involved-20in-20intracellular-20as-20well-20as-20in-20extracellular-20signalling-20of-20damage.-20Here,-20we-20have-20initiated-20a-20study-20that-20addresses-20how-20mitochondria-2Dnucleus-20communication-20may-20occur-20in-20conditions-20of-20combined-20mitochondrial-20dysfunction-20and-20genotoxic-20stress-20and-20what-20are-20the-20consequences-20of-20this-20interaction-20on-20the-20cell-20system.-20In-20this-20work,-20we-20used-20cells-20deficient-20for-20PINK1,-20a-20mitochondrial-20kinase-20involved-20in-20mitochondrial-20quality-20control-20whose-20loss-20of-20function-20leads-20to-20the-20accumulation-20of-20dysfunctional-20mitochondria,-20challenged-20with-20inducers-20of-20DNA-20damage,-20namely,-20ionizing-20radiation-20and-20the-20radiomimetic-20bleomycin.-20Combined-20stress-20at-20the-20level-20of-20mitochondria-20and-20the-20nucleus-20impairs-20both-20mitochondrial-20and-20nuclear-20functions.-20Our-20findings-20revealed-20exacerbated-20sensibility-20to-20genotoxic-20stress-20in-20PINK1-2Ddeficient-20cells.-20The-20same-20cells-20showed-20an-20impaired-20induction-20of-20bystander-20phenomena-20following-20stress-20insults.-20However,-20these-20cells-20responded-20adaptively-20when-20a-20challenge-20dose-20was-20applied-20subsequently-20to-20a-20low-2Ddose-20treatment-20to-20the-20cells.-20The-20data-20demonstrates-20that-20PINK1-20modulates-20intracellular-20and-20intercellular-20signalling-20pathways,-20particularly-20adaptive-20responses-20and-20transmission-20of-20bystander-20signalling,-20two-20facets-20of-20the-20cell-2Dprotective-20mechanisms-20against-20detrimental-20agents." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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