Cookies help us deliver our services. By using our services, you agree to our use of cookies. More information

Search by property

From Bioblast

This page provides a simple browsing interface for finding entities described by a property and a named value. Other available search interfaces include the page property search, and the ask query builder.

Search by property

Property "Has-20abstract" (as page type) with input value "Medium-2Dchain-20acyl-2DCoA-20dehydrogenase-20(MCAD)-20deficiency-20is-20biochemically-20characterized-20by-20tissue-20accumulation-20of-20octanoic-20(OA),-20decanoic-20(DA)-20and-20cis-2D4-2Ddecenoic-20(cDA)-20acids,-20as-20well-20as-20by-20their-20carnitine-20by-2Dproducts.-20Untreated-20patients-20present-20episodic-20encephalopathic-20crises-20and-20biochemical-20liver-20alterations,-20whose-20pathophysiology-20is-20poorly-20known.-20We-20investigated-20the-20effects-20of-20OA,-20DA,-20cDA,-20octanoylcarnitine-20(OC)-20and-20decanoylcarnitine-20(DC)-20on-20critical-20mitochondrial-20functions-20in-20rat-20brain-20and-20liver.-20DA-20and-20cDA-20increased-20resting-20respiration-20and-20diminished-20ADP-2D-20and-20CCCP-2Dstimulated-20respiration-20and-20complexes-20II-2DIII-20and-20IV-20activities-20in-20both-20tissues.-20The-20data-20indicate-20that-20these-20compounds-20behave-20as-20uncouplers-20and-20metabolic-20inhibitors-20of-20oxidative-20phosphorylation.-20Noteworthy,-20metabolic-20inhibition-20was-20more-20evident-20in-20brain-20as-20compared-20to-20liver.-20DA-20and-20cDA-20also-20markedly-20decreased-20mitochondrial-20membrane-20potential,-20NAD(P)H-20content-20and-20Ca-3Csub-3E2+-3C-2Fsub-3E-20retention-20capacity-20in-20Ca-3Csub-3E2+-3C-2Fsub-3E-2Dloaded-20brain-20and-20liver-20mitochondria.-20The-20reduction-20of-20Ca-3Csub-3E2+-3C-2Fsub-3E-20retention-20capacity-20was-20more-20pronounced-20in-20liver-20and-20totally-20prevented-20by-20cyclosporine-20A-20and-20ADP,-20as-20well-20as-20by-20ruthenium-20red,-20demonstrating-20the-20involvement-20of-20mitochondrial-20permeability-20transition-20(mPT)-20and-20Ca-3Csub-3E2+-3C-2Fsub-3E.-20Furthermore,-20cDA-20induced-20lipid-20peroxidation-20in-20brain-20and-20liver-20mitochondria-20and-20increased-20hydrogen-20peroxide-20formation-20in-20brain,-20suggesting-20the-20participation-20of-20oxidative-20damage-20in-20cDA-2Dinduced-20alterations.-20Interestingly,-20OA,-20OC-20and-20DC-20did-20not-20alter-20the-20evaluated-20parameters,-20implying-20lower-20toxicity-20for-20these-20compounds.-20Our-20results-20suggest-20that-20DA-20and-20cDA,-20in-20contrast-20to-20OA-20and-20medium-2Dchain-20acylcarnitines,-20disturb-20important-20mitochondrial-20functions-20in-20brain-20and-20liver-20by-20multiple-20mechanisms-20that-20are-20possibly-20involved-20in-20the-20neuropathology-20and-20liver-20alterations-20observed-20in-20MCAD-20deficiency.-0A-0ACopyright-20©-202016-20Elsevier-20B.V.-20All-20rights-20reserved." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

Showing below up to 0 results starting with #1.

View (previous 50 | next 50) (20 | 50 | 100 | 250 | 500)


    

List of results

No results.