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Property "Has-20abstract" (as page type) with input value "Mitochondrial-20biogenesis,-20which-20depends-20on-20nuclear-20as-20well-20as-20mitochondrial-0Agenes,-20occurs-20in-20response-20to-20increased-20cellular-20ATP-20demand.-20The-20nuclear-20transcriptional-20factors,-20estrogen-2Drelated-20receptor-20a-20(ERRa)-20and-20nuclear-20respiratory-20factors-201-20and-202,-20are-20associated-20with-20the-20coordination-20of-20the-20transcriptional-20machinery-20governing-20mitochondrial-20biogenesis,-20whereas-20coactivators-20of-20the-20peroxisome-20proliferator-2Dactivated-20receptor-20c-20coactivator-2D-0A1-20(PGC-2D1)-20family-20serve-20as-20mediators-20between-20the-20environment-20and-20this-20machinery.-20In-20the-20context-20of-20proliferating-20cells,-20PGC-2D1-2Drelated-20coactivator(PRC)-20is-20a-20member-20of-20the-20PGC-2D1-20family,-20which-20is-20known-20to-20act-20in-20partnership-20with-20nuclear-20respiratory-20factors,-20but-20no-20functional-20interference-20between-20PRC-20and-20ERRa-20has-20been-20described-20so-20far.-20We-20explored-20three-20thyroid-20cell-20lines,-20FTC-2D133,-20XTC.UC1-20and-20RO-2082-20W-2D1,-20each-20characterized-20by-20a-20different-20mitochondrial-20content,-20and-20studied-20their-20behavior-20towards-20PRC-20and-20ERRa-20in-20terms-20of-20respiratory-20efficiency.-20Overexpression-20of-20PRC-20and-20ERRa-20led-20to-20increased-20respiratory-20chain-20capacity-20and-20mitochondrial-20mass.-20The-20inhibition-20of-20ERRa-20decreased-20cell-20growth-20and-20respiratory-20chain-20capacity-20in-20all-20three-20cell-20lines.-20However,-20the-20inhibition-20of-20PRC-20and-20ERRa-20produced-20a-20greater-20effect-20in-20the-20oxidative-20cell-20model,-20decreasing-20the-20mitochondrial-20mass-20and-20the-20phosphorylating-20respiration,-20whereas-20the-20nonphosphorylating-20respiration-20remained-20unchanged.-20We-20therefore-20hypothesize-0Athat-20the-20ERRa–PRC-20complex-20plays-20a-20role-20in-20arresting-20the-20cell-20cycle-0Athrough-20the-20regulation-20of-20oxidative-20phosphorylation-20in-20oxidative-20cells,-20and-0Athrough-20some-20other-20pathway-20in-20glycolytic-20cells." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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