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This page provides a simple browsing interface for finding entities described by a property and a named value. Other available search interfaces include the page property search, and the ask query builder.

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Property "Has-20abstract" (as page type) with input value "Mitochondrial-20cristae-20are-20connected-20to-20the-20inner-20boundary-20membrane-20via-20crista-20junctions-20which-20are-20implicated-20in-20the-20regulation-20of-20oxidative-20phosphorylation,-20apoptosis,-20and-20import-20of-20lipids-20and-20proteins.-20The-20MICOS-20complex-20determines-20formation-20of-20crista-20junctions.-20We-20performed-20complexome-20profiling-20and-20identified-20Mic13,-20also-20termed-20Qil1,-20as-20a-20subunit-20of-20the-20MICOS-20complex.-20We-20show-20that-20MIC13-20is-20an-20inner-20membrane-20protein-20physically-20interacting-20with-20MIC60,-20a-20central-20subunit-20of-20the-20MICOS-20complex.-20Using-20the-20CRISPR-2FCas-20method-20we-20generated-20the-20first-20cell-20line-20deleted-20for-20MIC13.-20These-20knockout-20cells-20show-20a-20complete-20loss-20of-20crista-20junctions-20demonstrating-20that-20MIC13-20is-20strictly-20required-20for-20the-20formation-20of-20crista-20junctions.-20MIC13-20is-20required-20for-20the-20assembly-20of-20MIC10,-20MIC26,-20and-20MIC27-20into-20the-20MICOS-20complex.-20However,-20it-20is-20not-20needed-20for-20the-20formation-20of-20the-20MIC60-2FMIC19-2FMIC25-20subcomplex-20suggesting-20that-20the-20latter-20is-20not-20sufficient-20for-20crista-20junction-20formation.-20MIC13-20is-20also-20dispensable-20for-20assembly-20of-20respiratory-20chain-20complexes-20and-20for-20maintaining-20mitochondrial-20network-20morphology.-20Still,-20lack-20of-20MIC13-20resulted-20in-20a-20moderate-20reduction-20of-20mitochondrial-20respiration.-20In-20summary,-20we-20show-20that-20MIC13-20has-20a-20fundamental-20role-20in-20crista-20junction-20formation-20and-20that-20assembly-20of-20respiratory-20chain-20supercomplexes-20is-20independent-20of-20mitochondrial-20cristae-20shape." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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