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Property "Has-20abstract" (as page type) with input value "Mitochondrial-20efficiency-20is-20typically-20taken-20to-20represent-20an-20animal's-20capacity-20to-20convert-20its-20resources-20into-20ATP.-20However,-20the-20term-20mitochondrial-20efficiency,-20as-20currently-20used-20in-20the-20literature,-20can-20be-20calculated-20as-20either-20the-20respiratory-20control-20ratio,-20RCR-20(ratio-20of-20mitochondrial-20respiration-20supporting-20ATP-20synthesis-20to-20that-20required-20to-20offset-20the-20proton-20leak)-20or-20as-20the-20amount-20of-20ATP-20generated-20per-20unit-20of-20oxygen-20consumed,-20ATP-2FO-20ratio.-20The-20question-20of-20how-20flexibility-20in-20mitochondrial-20energy-20properties-20(i.e.-20in-20rates-20of-20respiration-20to-20support-20ATP-20synthesis-20and-20offset-20proton-20leak,-20and-20in-20the-20rate-20of-20ATP-20synthesis)-20affects-20these-20indices-20of-20mitochondrial-20efficiency-20has-20tended-20to-20be-20overlooked.-20Furthermore,-20little-20is-20known-20of-20whether-20the-20RCR-20and-20ATP-2FO-20ratio-20vary-20in-20parallel,-20either-20among-20inspaniduals-20or-20in-20response-20to-20environmental-20conditions.-20Using-20data-20from-20brown-20trout-20-27-27Salmo-20trutta-27-27-20we-20show-20that-20experimental-20conditions-20affect-20mitochondrial-20efficiency,-20but-20the-20apparent-20direction-20of-20change-20depends-20on-20the-20index-20chosen:-20a-20reduction-20in-20food-20availability-20was-20associated-20with-20an-20increased-20RCR-20(i.e.-20increased-20efficiency)-20but-20a-20decreased-20ATP-2FO-20ratio-20(decreased-20efficiency)-20in-20liver-20mitochondria.-20Moreover,-20there-20was-20a-20negative-20correlation-20across-20inspaniduals-20held-20in-20identical-20conditions-20between-20their-20RCR-20and-20their-20ATP-2FO-20ratio.-20These-20results-20show-20that-20the-20choice-20of-20index-20of-20mitochondrial-20efficiency-20can-20produce-20different,-20even-20opposing,-20conclusions-20about-20the-20capacity-20of-20the-20mitochondria-20to-20produce-20ATP.-20Neither-20ratio-20is-20necessarily-20a-20complete-20measure-20of-20efficiency-20of-20ATP-20production-20in-20the-20living-20animal-20(RCR-20because-20it-20contains-20no-20assessment-20of-20ATP-20production,-20and-20ATP-2FO-20because-20it-20contains-20no-20assessment-20of-20respiration-20to-20offset-20the-20proton-20leak).-20Consequently,-20we-20suggest-20that-20a-20measure-20of-20mitochondrial-20efficiency-20obtained-20nearer-20to-20conditions-20where-20respiration-20simultaneously-20offsets-20the-20proton-20leak-20and-20produce-20ATP-20would-20be-20sensitive-20to-20changes-20in-20both-20proton-20leakage-20and-20ATP-20production,-20and-20is-20thus-20likely-20to-20be-20more-20representative-20of-20the-20state-20of-20the-20mitochondria-20-27-27in-20vivo-27-27." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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