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Property "Has-20abstract" (as page type) with input value "Obesity-20is-20often-20associated-20with-20abnormalities-20in-20cardiac-20morphology-20and-20function.-20This-20study-20tested-20the-20hypothesis-20that-20obesity-2Drelated-20cardiomyopathy-20is-20caused-20by-20impaired-20cardiac-20energetics.-20In-20a-20mouse-20model-20of-20high-2Dfat-20diet-20(HFD)-2Dinduced-20obesity,-20we-20applied-20-27-27in-20vivo-27-27-20cardiac-2031P-20magnetic-20resonance-20spectroscopy-20(MRS)-20and-20magnetic-20resonance-20imaging-20(MRI)-20to-20investigate-20cardiac-20energy-20status-20and-20function,-20respectively.-20The-20measurements-20were-20complemented-20by-20ex-20vivo-20determination-20of-20oxygen-20consumption-20in-20isolated-20cardiac-20mitochondria,-20the-20expression-20of-20proteins-20involved-20in-20energy-20metabolism,-20and-20markers-20of-20oxidative-20stress-20and-20calcium-20homeostasis.-20We-20also-20assessed-20whether-20HFD-20induced-20myocardial-20lipid-20accumulation-20using-20-27-27in-20vivo-27-27-201H-20MRS,-20and-20if-20this-20was-20associated-20with-20apoptosis-20and-20fibrosis.-20Twenty-20weeks-20of-20HFD-20feeding-20resulted-20in-20early-20stage-20cardiomyopathy,-20as-20indicated-20by-20diastolic-20dysfunction-20and-20increased-20left-20ventricular-20mass,-20without-20any-20effects-20on-20systolic-20function.-20-27-27In-20vivo-27-27-20cardiac-20phosphocreatine-2Dto-2DATP-20ratio-20and-20ex-20vivo-20oxygen-20consumption-20in-20isolated-20cardiac-20mitochondria-20were-20not-20reduced-20after-20HFD-20feeding,-20suggesting-20that-20the-20diastolic-20dysfunction-20was-20not-20caused-20by-20impaired-20cardiac-20energetics.-20HFD-20feeding-20promoted-20mitochondrial-20adaptations-20for-20increased-20utilization-20of-20fatty-20acids,-20which-20was-20however-20not-20sufficient-20to-20prevent-20the-20accumulation-20of-20myocardial-20lipids-20and-20lipid-20intermediates.-20Myocardial-20lipid-20accumulation-20was-20associated-20with-20oxidative-20stress-20and-20fibrosis,-20but-20not-20apoptosis.-20Furthermore,-20HFD-20feeding-20strongly-20reduced-20the-20phosphorylation-20of-20phospholamban,-20a-20prominent-20regulator-20of-20cardiac-20calcium-20homeostasis-20and-20contractility.-20In-20conclusion,-20HFD-2Dinduced-20early-20stage-20cardiomyopathy-20in-20mice-20is-20associated-20with-20lipotoxicity-2Dassociated-20oxidative-20stress,-20fibrosis,-20and-20disturbed-20calcium-20homeostasis,-20rather-20than-20impaired-20cardiac-20energetics." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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