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This page provides a simple browsing interface for finding entities described by a property and a named value. Other available search interfaces include the page property search, and the ask query builder.

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Property "Has-20abstract" (as page type) with input value "Obesity-2Dderived-20inflammation-20and-20metabolic-20dysfunction-20has-20been-20related-20to-20the-20activity-20of-20the-20inducible-20nitric-20oxide-20synthase-20(iNOS).-20To-20understand-20the-20interrelation-20between-20metabolism,-20obesity-20and-20NO.,-20we-20evaluated-20the-20effects-20of-20obesity-2Dinduced-20NO.-20signaling-20on-20liver-20mitochondrial-20function.-20We-20used-20mouse-20strains-20containing-20mitochondrial-20nicotinamide-20transhydrogenase-20activity,-20while-20prior-20studies-20involved-20a-20spontaneous-20mutant-20of-20this-20enzyme,-20and-20are,-20therefore,-20more-20prone-20to-20oxidative-20imbalance.-20Wild-2Dtype-20and-20iNOS-20knockout-20mice-20were-20fed-20a-20high-20fat-20diet-20for-202,-204-20or-208-20weeks.-20iNOS-20knockout-20did-20not-20protect-20against-20diet-2Dinduced-20metabolic-20changes.-20However,-20the-20diet-20decreased-20fatty-2Dacid-20oxidation-20capacity-20in-20liver-20mitochondria-20at-204-20weeks-20in-20both-20wild-2Dtype-20and-20knockout-20groups-3B-20this-20was-20recovered-20at-208-20weeks.-20Interestingly,-20other-20mitochondrial-20functional-20parameters-20were-20unchanged,-20despite-20significant-20modifications-20in-20insulin-20resistance-20in-20wild-20type-20and-20iNOS-20knockout-20animals.-20Overall,-20we-20found-20two-20surprising-20features-20of-20obesity-2Dinduced-20metabolic-20dysfunction:-20(i)-20iNOS-20does-20not-20have-20an-20essential-20role-20in-20obesity-2Dinduced-20insulin-20resistance-20under-20all-20experimental-20conditions-20and-20(ii)-20liver-20mitochondria-20are-20resilient-20to-20functional-20changes-20in-20obesity-2Dinduced-20metabolic-20dysfunction" contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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