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Property "Has-20abstract" (as page type) with input value "Omega-2D3-20polyunsaturated-20fatty-20acids-20(n-2D3-20PUFAs)-20enhance-20insulin-20sensitivity-20and-20glucose-20homeostasis-20in-20rodent-20models-20of-20insulin-20resistance.-20These-20beneficial-20effects-20have-20been-20linked-20with-20anti-2Dinflammatory-20properties,-20but-20emerging-20data-20suggest-20that-20the-20mechanisms-20may-20also-20converge-20on-20mitochondria.-20We-20evaluated-20the-20influence-20of-20dietary-20n-2D3-20PUFAs-20on-20mitochondrial-20physiology-20and-20muscle-20lipid-20metabolites-20in-20the-20context-20of-20high-2Dfat-20diet-20(HFD)-20in-20mice.-20Mice-20were-20fed-20control-20diets-20(10-25-20fat),-20HFD-20(60-25-20fat),-20or-20HFD-20with-20fish-20oil-20(HFD+FO,-203.4-25-20kcal-20from-20n-2D3-20PUFAs)-20for-2010-20wk.-20Body-20mass-20and-20fat-20mass-20increased-20similarly-20in-20HFD-20and-20HFD+FO,-20but-20n-2D3-20PUFAs-20attenuated-20the-20glucose-20intolerance-20that-20developed-20with-20HFD-20and-20increased-20expression-20of-20genes-20that-20regulate-20glucose-20metabolism-20in-20skeletal-20muscle.-20Despite-20similar-20muscle-20triglyceride-20levels-20in-20HFD-20and-20HFD+FO,-20long-2Dchain-20acyl-2DCoAs-20and-20ceramides-20were-20lower-20in-20the-20presence-20of-20fish-20oil.-20Mitochondrial-20abundance-20and-20oxidative-20capacity-20were-20similarly-20increased-20in-20HFD-20and-20HFD+FO-20compared-20with-20controls.-20Hydrogen-20peroxide-20production-20was-20similarly-20elevated-20in-20HFD-20and-20HFD+FO-20in-20isolated-20mitochondria-20but-20not-20in-20permeabilized-20muscle-20fibers,-20likely-20due-20to-20increased-20activity-20and-20expression-20of-20catalase.-20These-20results-20support-20a-20hypothesis-20that-20n-2D3-20PUFAs-20protect-20glucose-20tolerance,-20in-20part-20by-20preventing-20the-20accumulation-20of-20bioactive-20lipid-20mediators-20that-20interfere-20with-20insulin-20action.-20Furthermore,-20the-20respiratory-20function-20of-20skeletal-20muscle-20mitochondria-20does-20not-20appear-20to-20be-20a-20major-20factor-20in-20sphingolipid-20accumulation,-20glucose-20intolerance,-20or-20the-20protective-20effects-20of-20n-2D3-20PUFAs." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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