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Property "Has-20abstract" (as page type) with input value "Recently,-20medicinal-20plants-20from-20ancient-20Ayurvedic-20medicine-20have-20provided-20clues-0Ato-20the-20discovery-20of-20novel-20therapeutics-20for-20various-20diseases.-20In-20Ayurvedi-20c-20medicine,-20a-0Acommon-20Indian-20plant,-20-27-27Centella-20asiatica-27-27-20is-20highly-20regarded-20as-20a-20"rasayana"-20or-20nerve-20tonic.-0AThe-20Centella-20extract-20is-20used-20to-20ward-20off-20age-2Drelated-20dementia-20and-20to-20increase-20memory-20and-0Aintelligence.-20The-20mechanism-20by-20which-20Centella-20improves-20memory-20and-20learning-20and-0Areduces-20the-20risk-20of-20dementia-20is-20unclear.-0A-0AWe-20recently-20tested-20the-20effects-20of-20asiatic-20acid,-20the-20main-20active-20component-20of-0ACentella,-20on-20neuronal-20growth.-20We-20hypothesized-20that-20asiatic-20acid-20will-20promote-20neuronal-0Agrowth-20and-20neurite-20network-20formation.-20To-20test-20this-20hypothesis,-20we-20examined-20the-20effects-0Aof-20asi-20atic-20acid-20on-20neuronal-20growth-20in-20murine-20neuroblastoma-20cells,-20Neuro2a.-20Neuro2a-20cells-0Awere-20cultured-20for-2024-20hours-20in-20DMEM-20medium-20containing-20lO-20mM-20glucose-20and-2010-25-20FBS-0Ain-20six-2Dwell-20plates-20at-20a-20concentration-20of-20200,000-20cell-20s-2Fwell.-20The-20cells-20were-20further-20cultured-0Afor-2072-20hours-20in-20DMEM-20containing-2010-20mM-20glucose-20and-20with-20either-201-20μM-20asiatic-20acid-20in-0Aethanol-20or-20ethanol-20alone-20(vehicle).-20Cells-20were-20photographed,-20and-20neurite-20outgrowth-0Aquantified-20using-20NeuronJ-20software.-20The-20results-20revealed-20that-20asiatic-20acid-20treatment-0Asignificantly-20increased-20the-20percentage-20of-20cells-20bearing-20neurites-20as-20compared-20to-20neurons-0Agrown-20in-20medium-20alone.-20In-20addition,-20asiatic-20acid-20treatment-20increased-20neurite-20extension-0Aand-20combined-20length-20of-20neurites.-20To-20investigate-20the-20impact-20of-20asiatic-20acid-20on-0Abioenergetics-20in-20Neuro2a-20cells,-20we-20first-20analyzed-20the-20electron-20transport-20chain-20of-20the-0Amitochondria-20via-20respirometry.-20The-20respiration-20rates-20of-20Neuro2a-20cells-20cultured-20in-0Amedium-20containing-20asiatic-20acid-20was-20significantly-20(p-3C-200.05)-20higher-20than-20cells-20grown-20in-20medium-20containing-20vehicle-20alone.-20Also,-20western-20blot-20analyses-20were-20used-20to-20examine-20if-0Aasiatic-20acid-20could-20increase-20the-20mitochondrial-20complex.-20The-20result-20showed-20that-20Asiatic-0Aacid-20increased-20complex-201,-202,-203,-20and-204.-20In-20addition,-20we-20examined-20if-20asiatic-20acid-20would-0Aincrease-20oxidative-20phosphorylation-20instead-20of-20glycolysis-20that-20results-20in-20l-20actate-20production.-0AThe-20results-20indicated-20that-20Neuro2a-20cells-20treated-20for-2024-20hours-20with-201-20μM-20of-20asiatic-20acid-0Ainduced-20less-20lactate-20as-20compared-20to-20Neuro2a-20with-20ethanol-20alone-20(vehicle).-20Also,-20the-20MTT-0Aassay-20was-20used-20to-20detect-20the-20viable-20cells-20in-20Neuro2a-20cells-20treated-20with-20either-20l-20μM-20asiatic-0Aacid-20or-20ethanol-20alone-20(vehicle)-20for-20two-20days.-20The-20result-20shows-20that-20Neuro2a-20cells-20treated-0Awith-20asiatic-20acid-20showed-20increased-20cell-20viability-20as-20compared-20to-20Neuro2a-20exposed-20to-0Aethanol-20alone.-20Finally,-20the-20effect-20of-20asiatic-20acid-20on-20cell-20proliferation-20was-20examined-20using-0Astandard-20trypan-20blue-20staining.-20The-20data-20revealed-20that-20doubling-20time-20was-20significantly-0Aslower-20in-20cells-20cultured-20in-20presence-20of-20asiatic-20acid-20as-20compared-20to-20cells-20grown-20in-20vehicle-0A(ethanol)-20alone-20(p-3C-200.-2005).-0A-0ATogether-20these-20results-20suggest-20that-20asiatic-20acid-20is-20neurotrophic.-20This-20effect-20may-0Aexplain-20the-20beneficial-20role-20of-20-27-27Centella-20asiatica-27-27-20extract-20on-20learning-20and-20memory-20and-20in-0Apreventing-20neurological-20disorders." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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