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Property "Has-20abstract" (as page type) with input value "Reprogramming-20of-20energy-20metabolism-20is-20a-20hallmark-20of-20cancer.-20Mutations-20in-20the-20mitochondrial-20DNA-20(mtDNA)-20might-20contribute-20to-20cancer-20development-20and-20progression.-20We-20analyzed-20mitochondrial-20respiration-20of-20fresh-20malignant-20and-20non-2Dmalignant-20prostate-20tissue-20samples-20obtained-20from-2050-20prostate-20cancer-20patients-20by-20high-2Dresolution-20respirometry-20(HRR),-20determined-20mtDNA-20copy-20numbers-20by-20duplex-20qPCR,-20sequenced-20the-20whole-20mtDNAs-20using-20next-2Dgeneration-20sequencing-20(NGS)-20and-20analyzed-20expression-20of-20mt-2Drelated-20genes-20in-20a-20subset-20of-2016-20cases-20by-20RNA-2Dsequencing.-20HRR-20uncovered-20a-20shift-20of-20respiratory-20activity-20from-20the-20glutamate-26malate-20to-20pyruvate-20and-20succinate-2Dpathways.-20The-20mutation-20load-20was-20significantly-20higher-20in-20tumor-20tissue-20compared-20to-20the-20non-2Dmalignant-20counterpart.-20Heteroplasmy-20levels-20of-20potentially-20deleterious-20mutations-20in-20mtDNA-20genes-20correlated-20significantly-20with-20reduced-20NADH-2Dlinked-20respiratory-20capacity.-20RNA-2Dseq-20revealed-20a-20signature-20of-20differentially-20expressed-20metabolic-20enzymes-20in-20tumors-20exhibiting-20a-20severe-20compared-20to-20a-20mild-20NADH-2Dpathway-20mt-2Dphenotype.-20The-20gene-20signature-20corresponded-20to-20observed-20altered-20substrates-20effects-20on-20respiration,-20e.g.-20increased-20pyruvate-20and-20citrate-20and-20decreased-20glutamate-20oxidation." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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