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Property "Has-20abstract" (as page type) with input value "Resveratrol-20(RSV)-20is-20a-20polyphenolic-20compound-20suggested-20to-20have-20anti-2Ddiabetic-20properties.-20Surprisingly,-20little-20is-20known-20regarding-20the-20effects-20of-20RSV-20supplementation-20on-20adipose-20tissue-20(AT)-20metabolism-20-27-27in-20vivo-27-27.-20The-20purpose-20of-20this-20study-20was-20to-20assess-20the-20effects-20of-20RSV-20on-20mitochondrial-20content-20and-20respiration,-20glyceroneogenesis-20(GNG),-20and-20adiponectin-20secretion-20in-20adipose-20tissue-20from-20Zucker-20diabetic-20fatty-20(ZDF)-20rats.-20Five-2Dweek-2Dold-20ZDF-20rats-20were-20fed-20a-20chow-20diet-20with-20(ZDF-20RSV)-20or-20without-20(ZDF-20chow)-20RSV-20(200-20mg-2Fkg-20body-20wt)-20for-206-20wk.-20Changes-20in-20adipose-20tissue-20metabolism-20were-20assessed-20in-20subcutaneous-20(scAT)-20and-20intra-2Dabdominal-20-5Bretroperitoneal-20(rpWAT),-20epididymal-20(eWAT)-5D-20adipose-20tissue-20depots.-20ZDF-20RSV-20rats-20showed-20lower-20fasting-20glucose-20and-20higher-20circulating-20adiponectin,-20as-20well-20as-20lower-20glucose-20area-20under-20the-20curve-20during-20intraperitoneal-20glucose-20and-20insulin-20tolerance-20tests-20than-20ZDF-20chow.-20-5B¹⁴C-5Dpyruvate-20incorporation-20into-20triglycerides-20and-20adiponectin-20secretion-20were-20higher-20in-20scAT-20from-20ZDF-20RSV-20rats,-20concurrent-20with-20increases-20in-20adipose-20tissue-20triglyceride-20lipase-20(ATGL),-20hormone-2Dsensitive-20lipase-20(HSL),-20and-20the-20phosphorylation-20of-20pyruvate-20dehydrogenase-2DE1α-20(PDH)-20(Ser293)-20protein-20content-20in-20this-20depot.-20Moreover,-20uncoupled-20mitochondrial-20respiration-20and-20complex-20I-20and-20II-2Dsupported-20respiration-20were-20increased-20in-20both-20scAT-20and-20rpWAT,-20which-20correlated-20with-20increases-20in-20cytochrome-20c-20oxidase-20subunit-20IV-20(COX4)-20protein-20content.-20-27-27In-20vitro-27-27-20treatment-20of-20scAT-20with-20RSV-20(50-20μmol-2Fl-3B-2024-20h)-20induced-20pyruvate-20dehydrogenase-20kinase-204-20(PDK4)-20and-20peroxisome-20proliferator-2Dactivated-20receptor-20(PPAR)-2Dγ-20coactivator-2D1α-20(PGC-2D1α)-20mRNA-20expression.-20Collectively,-20these-20data-20demonstrate-20that-20RSV-20can-20induce-20adipose-20tissue-20mitochondrial-20biogenesis-20in-20parallel-20with-20increases-20in-20GNG-20and-20adiponectin-20secretion." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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