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This page provides a simple browsing interface for finding entities described by a property and a named value. Other available search interfaces include the page property search, and the ask query builder.

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Property "Has-20abstract" (as page type) with input value "Skeletal-20muscle-20is-20a-20key-20organ-20of-20mammalian-20energy-20metabolism,-20and-20its-20mitochondria-20are-20multifunction-20organelles-20that-20are-20targets-20of-20dietary-20bioactive-20compounds.-20The-20goal-20of-20this-20work-20was-20to-20examine-20the-20regulation-20of-20mitochondrial-20dynamics,-20functionality-20and-20cell-20energy-20parameters-20using-20docosahexaenoic-20acid-20(DHA),-20epigallocatechin-20gallate-20(EGCG)-20and-20a-20combination-20of-20both-20in-20L6-20myocytes.-20Compounds-20(at-2025ΞM)-20were-20incubated-20for-204-20hours.-20Cells-20cultured-20with-20DHA-20displayed-20a-20less-20oxygen-20consumption-20with-20a-20higher-20ADP-2FATP-20ratio-20levels-20concomitant-20with-20downregulation-20of-20Cox-20and-20Ant1-20genes-20expression.-20The-20disruption-20of-20energetic-20homeostasis-20by-20DHA,-20increase-20intracellular-20reactive-20oxygen-20species-20(ROS)-20levels-20and-20decrease-20mitochondrial-20membrane-20potential.-20The-20defence-20mechanism-20to-20counteract-20the-20excess-20of-20ROS-20production-20was-20by-20the-20upregulation-20of-20Ucp2,-20Ucp3-20and-20Mnsod-20genes-20expression.-20Moreover-20myocytes-20cultured-20with-20DHA-20had-20a-20higher-20mitochondrial-20mass-20with-20a-20higher-20proportion-20of-20large-20and-20elongated-20mitochondria,-20whereas-20the-20fission-20genes-20Drp1-20and-20Fiss1-20and-20the-20fusion-20gene-20Mfn2-20were-20downregulated.-20In-20myocytes-20co-2Dincubated-20with-20DHA-20and-20EGCG-3B-20ROS-20levels-20and-20the-20ADP-2FATP-20ratio-20were-20similar-20to-20untreated-20myocytes-20and-20the-20decrease-20of-20oxygen-20consumption,-20higher-20mitochondrial-20mass-20and-20the-20overexpression-20of-20Ucp2-20and-20Ucp3-20genes-20were-20similar-20to-20the-20DHA-2Dtreated-20cells-20with-20also-20higher-20amount-20of-20mitochondrial-20DNA,-20and-20reduced-20Drp1,-20Fiss1-20gene-20expression-20levels.-20In-20conclusion-20the-20addition-20of-20EGCG-20to-20DHA-20returned-20the-20cells-20to-20the-20control-20conditions-20in-20terms-20of-20mitochondrial-20morphology,-20energy-20and-20redox-20status,-20which-20were-20unbalanced-20in-20the-20DHA-2Dtreated-20myocytes." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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