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This page provides a simple browsing interface for finding entities described by a property and a named value. Other available search interfaces include the page property search, and the ask query builder.

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Property "Has-20abstract" (as page type) with input value "Somatic-20mutations-20in-20the-20mitochondrial-20genome-20(mtDNA)-20have-20been-20linked-20to-20multiple-20disease-20conditions-20and-20to-20ageing-20itself.-20In-20-27-27Drosophila-27-27,-20knock-2Din-20of-20a-20proofreading-20deficient-20mtDNA-20polymerase-20(POLG)-20generates-20high-20levels-20of-20somatic-20point-20mutations-20and-20also-20small-20indels,-20but-20surprisingly-20limited-20impact-20on-20organismal-20longevity-20or-20fitness.-20Here-20we-20describe-20a-20new-20mtDNA-20mutator-20model-20based-20on-20a-20mitochondrially-2Dtargeted-20cytidine-20deaminase,-20APOBEC1.-20-27-27mito-27-27-2DAPOBEC1-20acts-20as-20a-20potent-20mutagen-20which-20exclusively-20induces-20C:G-3ET:A-20transitions-20with-20no-20indels-20or-20mtDNA-20depletion.-20In-20these-20flies,-20the-20presence-20of-20multiple-20non-2Dsynonymous-20substitutions,-20even-20at-20modest-20heteroplasmy,-20disrupts-20mitochondrial-20function-20and-20dramatically-20impacts-20organismal-20fitness.-20A-20detailed-20analysis-20of-20the-20mutation-20profile-20in-20the-20POLG-20and-20-27-27mito-27-27-2DAPOBEC1-20models-20reveals-20that-20mutation-20type-20(quality)-20rather-20than-20quantity-20is-20a-20critical-20factor-20in-20impacting-20organismal-20fitness.-20The-20specificity-20for-20transition-20mutations-20and-20the-20severe-20phenotypes-20make-20-27-27mito-27-27-2DAPOBEC1-20an-20excellent-20mtDNA-20mutator-20model-20for-20ageing-20research." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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