Search by property

Property "Has-20abstract" (as page type) with input value "Sporadic-20Parkinson's-20disease-20(sPD)-20is-20a-20nervous-20system-2Dwide-20disease-20that-20presents-20with-20a-20bradykinetic-20movement-20disorder-20and-20frequently-20progresses-20to-20include-20depression-20and-20cognitive-20impairment.-20Cybrid-20models-20of-20sPD-20are-20based-20on-20expression-20of-20sPD-20platelet-20mitochondrial-20DNA-20(mtDNA)-20in-20neural-20cells-20and-20demonstrate-20some-20similarities-20to-20sPD-20brains.-20In-20sPD-20and-20CTL-20cybrids-20we-20characterized-20aspects-20of-20mitochondrial-20biogenesis,-20mtDNA-20genomics,-20composition-20of-20the-20respirasome-20and-20the-20relationships-20among-20isolated-20mitochondrial-20and-20intact-20cell-20respiration.-20Cybrid-20mtDNA-20levels-20varied-20and-20correlated-20with-20expression-20of-20-5B-5BPGC-2D1alpha-7CPGC-2D1-20alpha-5D-5D,-20a-20transcriptional-20co-2Dactivator-20regulator-20of-20mitochondrial-20biogenesis.-20Levels-20of-20mtDNA-20heteroplasmic-20mutations-20were-20asymmetrically-20distributed-20across-20the-20mitochondrial-20genome-3B-20numbers-20of-20heteroplasmies-20were-20more-20evenly-20distributed.-20Neither-20levels-20nor-20numbers-20of-20heteroplasmies-20distinguished-20sPD-20from-20CTL.-20sPD-20cybrid-20mitochondrial-20ETC-20subunit-20protein-20levels-20were-20not-20altered.-20Isolated-20mitochondrial-20complex-20I-20respiration-20rates-20showed-20limited-20correlation-20with-20whole-20cell-20complex-20I-20respiration-20rates-20in-20both-20sPD-20and-20CTL-20cybrids.-20Intact-20cell-20respiration-20during-20the-20normoxic-2Danoxic-20transition-20yielded-20K(m)-20values-20for-20oxygen-20that-20directly-20related-20to-20respiration-20rates-20in-20CTL-20but-20not-20in-20sPD-20cell-20lines.-20Both-20sPD-20and-20CTL-20cybrid-20cells-20are-20substantially-20heterogeneous-20in-20mitochondrial-20genomic-20and-20physiologic-20properties.-20Our-20results-20suggest-20that-20mtDNA-20depletion-20may-20occur-20in-20sPD-20neurons-20and-20could-20reflect-20impairment-20of-20mitochondrial-20biogenesis.-20Cybrids-20remain-20a-20valuable-20model-20for-20some-20aspects-20of-20sPD-20but-20their-20heterogeneity-20mitigates-20against-20a-20simple-20designation-20of-20sPD-20phenotype-20in-20this-20cell-20model." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

Showing below up to 0 results starting with #1.

View (previous 50 | next 50) (20 | 50 | 100 | 250 | 500)