Search by property

Property "Has-20abstract" (as page type) with input value "Statins-20are-20used-20to-20lower-20cholesterol-20in-20plasma-20and-20are-20one-20of-20the-20most-20used-20drugs-20in-20the-20world.-20Many-20statin-20users-20experience-20muscle-20pain,-20but-20the-20mechanisms-20are-20unknown-20at-20the-20moment.-20Many-20studies-20have-20hypothesized-20that-20mitochondrial-20function-20could-20be-20involved-20in-20these-20side-20effects.-0A-0AThe-20aim-20of-20the-20study-20was-20to-20investigate-20mitochondrial-20function-20after-202-20weeks-20of-20treatment-20with-20simvastatin-20(S-3B-20n-20=-2010)-20or-20pravastatin-20(P-3B-20n-20=-2010)-20in-20healthy-20middle-2Daged-20participants.-0A-0AMitochondrial-20respiratory-20capacity-20and-20substrate-20sensitivity-20were-20measured-20in-20permeabilized-20muscle-20fibers-20by-20high-2Dresolution-20respirometry.-20Mitochondrial-20content-20(citrate-20synthase-20(CS)-20activity),-20antioxidant-20content,-20as-20well-20as-20coenzyme-20Q-3Csub-3E10-3C-2Fsub-3E-20concentration-20(Q-3Csub-3E10-3C-2Fsub-3E)-20were-20determined.-20Fasting-20plasma-20glucose-20and-20insulin-20concentrations-20were-20measured,-20and-20whole-20body-20maximal-20oxygen-20uptake-20(-27-27V-27-27-3Csub-3EO2max-3C-2Fsub-3E)-20was-20determined.-0A-0ANo-20differences-20were-20seen-20in-20mitochondrial-20respiratory-20capacity-20although-20a-20tendency-20was-20observed-20for-20a-20reduction-20when-20complex-20IV-20respiration-20was-20analyzed-20in-20both-20S-20(229-20(169-3B-20289-20(95-25-20confidence-20interval))-20vs.-20179-20(146-3B-20211)-20pmol-2Fs-2Fmg,-20respectively-3B-20P-20=-200.062)-20and-20P-20(214-20(143-3B-20285)-20vs.-20162-20(104-3B-20220)-20pmol-2Fs-2Fmg,-20respectively-3B-20P-20=-200.053)-20after-20treatment.-20A-20tendency-20(1.64-20(1.28-3B-202.00)-20vs.-201.28-20(0.99-3B-201.58)-20mM,-20respectively-3B-20P-20=-200.092)-20for-20an-20increased-20mitochondrial-20substrate-20sensitivity-20(complex-20I-2Dlinked-20substrate-3B-20glutamate)-20was-20seen-20only-20in-20S-20after-20treatment.-20No-20differences-20were-20seen-20in-20Q-3Csub-3E10-3C-2Fsub-3E,-20CS-20activity,-20or-20antioxidant-20content-20after-20treatment.-20Fasting-20glucose-20and-20insulin-20as-20well-20as-20-27-27V-27-27-3Csub-3EO2max-3C-2Fsub-3E-20were-20not-20changed-20after-20treatment.-0A-0ATwo-20weeks-20of-20statin-20(S-20or-20P)-20treatment-20have-20no-20major-20effect-20on-20mitochondrial-20function.-20The-20tendency-20for-20an-20increased-20mitochondrial-20substrate-20sensitivity-20after-20simvastatin-20treatment-20could-20be-20an-20early-20indication-20of-20the-20negative-20effects-20linked-20to-20statin-20treatment." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

Showing below up to 0 results starting with #1.

View (previous 50 | next 50) (20 | 50 | 100 | 250 | 500)