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Property "Has-20abstract" (as page type) with input value "The-207WD4-20and-207PA2-20cell-20lines,-20widely-20used-20as-20cellular-20models-20for-20Alzheimer's-20disease-20(AD),-20have-20been-20used-20to-20investigate-20the-20effects-20of-20amyloid-2Dβ-20protein-20precursor-20overexpression-20and-20amyloid-2Dβ-20(Aβ)-20oligomer-20accumulation-20on-20mitochondrial-20function.-20Under-20standard-20culture-20conditions,-20both-20cell-20lines,-20compared-20to-20Chinese-20hamster-20ovary-20(CHO)-20control-20cells,-20displayed-20an-20~5-25-20decrease-20of-20O2-20respiration-20as-20sustained-20by-20endogenous-20substrates.-20Functional-20impairment-20of-20the-20respiratory-20chain-20was-20found-20distributed-20among-20the-20protein-20complexes,-20though-20more-20evident-20at-20the-20level-20of-20complex-20I-20and-20complex-20IV.-20Measurements-20of-20ATP-20showed-20that-20its-20synthesis-20by-20oxidative-20phosphorylation-20is-20decreased-20in-207WD4-20and-207PA2-20cells-20by-20~25-25,-20this-20loss-20being-20partly-20compensated-20by-20glycolysis-20(Warburg-20effect).-20Compensation-20proved-20to-20be-20more-20efficient-20in-207WD4-20than-20in-207PA2-20cells,-20the-20latter-20cell-20line-20displaying-20the-20highest-20reactive-20oxygen-20species-20production.-20The-20strongest-20deficit-20was-20observed-20in-20mitochondrial-20membrane-20potential-20that-20is-20almost-2040-25-20and-2060-25-20lower-20in-207WD4-20and-207PA2-20cells,-20respectively,-20in-20comparison-20to-20CHO-20controls.-20All-20functional-20parameters-20point-20to-20a-20severe-20bioenergetic-20impairment-20of-20the-20AD-20cells,-20with-20the-20extent-20of-20mitochondrial-20dysfunction-20being-20correlated-20to-20the-20accumulation-20of-20Aβ-20peptides-20and-20oligomers." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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