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Property "Has-20abstract" (as page type) with input value "The-20aim-20of-20this-20study-20was-20to-20determine-20the-20impact-20of-20diabetes-20on-20oxidant-20balance-20and-20mitochondrial-20metabolism-20of-20carbohydrate-2D-20and-20lipid-2Dbased-20substrates-20in-20myocardium-20of-20type-202-20diabetic-20patients.-20Background-20Heart-20failure-20represents-20a-20major-20cause-20of-20death-20among-20diabetic-20patients.-20It-20has-20been-20proposed-20that-20derangements-20in-20cardiac-20metabolism-20and-20oxidative-20stress-20may-20underlie-20the-20progression-20of-20this-20comorbidity,-20but-20scarce-20evidence-20exists-20in-20support-20of-20this-20mechanism-20in-20humans.-20Methods-20Mitochondrial-20oxygen-20(O-3Csub-3E2-3C-2Fsub-3E)-20consumption-20and-20hydrogen-20peroxide-20(H-3Csub-3E2-3C-2Fsub-3EO-3Csub-3E2-3C-2Fsub-3E)-20emission-20were-20measured-20in-20permeabilized-20myofibers-20prepared-20from-20samples-20of-20the-20right-20atrial-20appendage-20obtained-20from-20nondiabetic-20(n=13)-20and-20diabetic-20(n=11)-20patients-20undergoing-20nonemergent-20coronary-20artery-20bypass-20graft-20surgery.-0AResults-20Mitochondria-20in-20atrial-20tissue-20of-20type-202-20diabetic-20inspaniduals-20show-20a-20sharply-20decreased-20capacity-20for-20glutamate-20and-20fatty-20acid-2Dsupported-20respiration,-20in-20addition-20to-20an-20increased-20content-20of-20myocardial-20triglycerides,-20as-20compared-20to-20nondiabetic-20patients.-20Furthermore,-20diabetic-20patients-20show-20an-20increased-20mitochondrial-20H-3Csub-3E2-3C-2Fsub-3EO-3Csub-3E2-3C-2Fsub-3E-20emission-20during-20oxidation-20of-20carbohydrate-2D-20and-20lipid-2Dbased-20substrates,-20depleted-20glutathione,-20and-20evidence-20of-20persistent-20oxidative-20stress-20in-20their-20atrial-20tissue.-0AConclusions-20These-20findings-20are-20the-20first-20to-20directly-20investigate-20the-20effects-20of-20type-202-20diabetes-20on-20a-20panoply-20of-20mitochondrial-20functions-20in-20the-20human-20myocardium-20using-20cellular-20and-20molecular-20approaches,-20and-20they-20show-20that-20mitochondria-20in-20diabetic-20human-20hearts-20have-20specific-20impairments-20in-20maximal-20capacity-20to-20oxidize-20fatty-20acids-20and-20glutamate,-20yet-20increased-20mitochondrial-20H-3Csub-3E2-3C-2Fsub-3EO-3Csub-3E2-3C-2Fsub-3E-20emission,-20providing-20insight-20into-20the-20role-20of-20mitochondrial-20dysfunction-20and-20oxidative-20stress-20in-20the-20pathogenesis-20of-20heart-20failure-20in-20diabetic-20patients." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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