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Property "Has-20abstract" (as page type) with input value "The-20circulating,-20endocrine-20renin-2Dangiotensin-20system-20(RAS)-20is-20important-20to-20circulatory-20homeostasis,-20while-20ubiquitous-20tissue-20and-20cellular-20RAS-20play-20spanerse-20roles,-20including-20metabolic-20regulation.-20Indeed,-20inhibition-20of-20RAS-20is-20associated-20with-20improved-20cellular-20oxidative-20capacity.-20Recently-20it-20has-20been-20suggested-20that-20an-20intra-2Dmitochondrial-20RAS-20directly-20impacts-20on-20metabolism.-20Here-20we-20sought-20to-20rigorously-20explore-20this-20hypothesis.-20Radiolabelled-20ligand-2Dbinding-20and-20unbiased-20proteomic-20approaches-20were-20applied-20to-20purified-20mitochondrial-20sub-2Dfractions-20from-20rat-20liver,-20and-20the-20impact-20of-20AngII-20on-20mitochondrial-20function-20assessed.-20Whilst-20high-2Daffinity-20AngII-20binding-20sites-20were-20found-20in-20the-20mitochondria-2Dassociated-20membrane-20(MAM)-20fraction,-20no-20RAS-20components-20could-20be-20detected-20in-20purified-20mitochondria.-20Moreover,-20AngII-20had-20no-20effect-20on-20the-20function-20of-20isolated-20mitochondria-20at-20physiologically-20relevant-20concentrations.-20We-20thus-20found-20no-20evidence-20of-20endogenous-20mitochondrial-20AngII-20production,-20and-20conclude-20that-20the-20effects-20of-20AngII-20on-20cellular-20energy-20metabolism-20are-20not-20mediated-20through-20its-20direct-20binding-20to-20mitochondrial-20targets." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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