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Property "Has-20abstract" (as page type) with input value "The-20mechanisms-20underlying-20the-20protective-20effect-20of-20monounsaturated-20fatty-20acids-20(e.g.-20oleate)-20against-20the-20lipotoxic-20action-20of-20saturated-20fatty-20acids-20(e.g.-20palmitate)-20in-20skeletal-20muscle-20cells-20remain-20poorly-20understood.-20This-20study-20aimed-20to-20examine-20the-20role-20of-20mitochondrial-20long-2Dchain-20fatty-20acid-20(LCFA)-20oxidation-20in-20mediating-20oleate's-20protective-20effect-20against-20palmitate-2Dinduced-20lipotoxicity.-20CPT1-20(carnitine-20palmitoyltransferase-201),-20which-20is-20the-20key-20regulatory-20enzyme-20of-20mitochondrial-20LCFA-20oxidation,-20is-20inhibited-20by-20malonyl-2DCoA,-20an-20intermediate-20of-20lipogenesis.-20We-20showed-20that-20expression-20of-20a-20mutant-20form-20of-20CPT1-20(CPT1mt),-20which-20is-20active-20but-20insensitive-20to-20malonyl-2DCoA-20inhibition,-20in-20C2C12-20myotubes-20led-20to-20increased-20LCFA-20oxidation-20flux-20even-20in-20the-20presence-20of-20high-20concentrations-20of-20glucose-20and-20insulin.-20Furthermore,-20similar-20to-20preincubation-20with-20oleate,-20CPT1mt-20expression-20protected-20muscle-20cells-20from-20palmitate-2Dinduced-20apoptosis-20and-20insulin-20resistance-20by-20decreasing-20the-20content-20of-20deleterious-20palmitate-20derivates-20(i.e.-20diacylglycerols-20and-20ceramides).-20Oleate-20preincubation-20exerted-20its-20protective-20effect-20by-20two-20mechanisms:-20(i)-20in-20contrast-20to-20CPT1mt-20expression,-20oleate-20preincubation-20increased-20the-20channeling-20of-20palmitate-20toward-20triglycerides,-20as-20a-20result-20of-20enhanced-20diacylglycerol-20acyltransferase-202-20expression,-20and-20(ii)-20oleate-20preincubation-20promoted-20palmitate-20oxidation-20through-20increasing-20CPT1-20expression-20and-20modulating-20the-20activities-20of-20acetyl-2DCoA-20carboxylase-20and-20AMP-2Dactivated-20protein-20kinase.-20In-20conclusion,-20we-20demonstrated-20that-20targeting-20mitochondrial-20LCFA-20oxidation-20via-20CPT1mt-20expression-20leads-20to-20the-20same-20protective-20effect-20as-20oleate-20preincubation,-20providing-20strong-20evidence-20that-20redirecting-20palmitate-20metabolism-20toward-20oxidation-20is-20sufficient-20to-20protect-20against-20palmitate-2Dinduced-20lipotoxicity." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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