Search by property

This page provides a simple browsing interface for finding entities described by a property and a named value. Other available search interfaces include the page property search, and the ask query builder.

Search by property

Property "Has-20abstract" (as page type) with input value "The-20metabolic-20properties-20of-20lymphomas-20derived-20from-20germinal-20center-20(GC)-20B-20cells-20have-20important-20implications-20for-20therapeutic-20strategies.-20In-20this-20study,-20we-20have-20compared-20metabolic-20features-20of-20Hodgkin-2DReed-2DSternberg-20(HRS)-20cells,-20the-20tumor-20cells-20of-20classical-20Hodgkin's-20lymphoma-20(cHL),-20one-20of-20the-20most-20frequent-20(post-2D)GC-2Dderived-20B-2Dcell-20lymphomas,-20with-20their-20normal-20GC-20B-20cell-20counterparts.-20We-20found-20that-20the-20ratio-20of-20oxidative-20to-20nonoxidative-20energy-20conversion-20was-20clearly-20shifted-20toward-20oxidative-20phosphorylation-20(OXPHOS)-2Dlinked-20ATP-20synthesis-20in-20HRS-20cells-20as-20compared-20to-20GC-20B-20cells.-20Mitochondrial-20mass,-20the-20expression-20of-20numerous-20key-20proteins-20of-20oxidative-20metabolism-20and-20markers-20of-20mitochondrial-20biogenesis-20were-20markedly-20upregulated-20in-20cHL-20cell-20lines-20and-20in-20primary-20cHL-20cases.-20NFkappaB-20promoted-20this-20shift-20to-20OXPHOS.-20Functional-20analysis-20indicated-20that-20both-20cell-20growth-20and-20viability-20of-20HRS-20cells-20depended-20on-20OXPHOS.-20The-20high-20rates-20of-20OXPHOS-20correlated-20with-20an-20almost-20complete-20lack-20of-20lactate-20production-20in-20HRS-20cells-20not-20observed-20in-20other-20GC-20B-2Dcell-20lymphoma-20cell-20lines.-20Overall,-20we-20conclude-20that-20OXPHOS-20dominates-20energy-20conversion-20in-20HRS-20cells,-20while-20nonoxidative-20ATP-20production-20plays-20a-20subordinate-20role.-20Our-20results-20suggest-20that-20OXPHOS-20could-20be-20a-20new-20therapeutic-20target-20and-20may-20provide-20an-20avenue-20toward-20new-20treatment-20strategies-20in-20cHL.-0A-0A©-202015-20UICC." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

Showing below up to 0 results starting with #1.

View (previous 50 | next 50) (20 | 50 | 100 | 250 | 500)

Property: Value:

List of results

No results.