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Property "Has-20abstract" (as page type) with input value "The-20paper-20considers-20the-20effects-20of-20bedaquiline-20(BDQ),-20an-20antituberculous-20preparation-20of-20the-20new-20generation,-20on-20rat-20liver-20mitochondria.-20It-20was-20shown-20that-2050 μM-20BDQ-20inhibited-20mitochondrial-20respiration-20measured-20with-20substrates-20of-20complexes-20I-20and-20II-20(glutamate-2Fmalate-20and-20succinate-2Frotenone-20systems-20respectively)-20in-20the-20states-20V-3Csub-3E3-3C-2Fsub-3E-20and-20V-3Csub-3EDNP-3C-2Fsub-3E.-20At-20the-20same-20time,-20at-20concentrations-20below-2050 μM,-20BDQ-20slightly-20stimulated-20respiration-20with-20substrates-20of-20complex-20I-20in-20the-20state-20V-3Csub-3E2-3C-2Fsub-3E.-20BDQ-20was-20also-20found-20to-20suppress,-20in-20a-20dose-2Ddependent-20manner,-20the-20activity-20of-20complex-20II-20and-20the-20total-20activity-20of-20complexes-20II + III-20of-20the-20mitochondrial-20transport-20chain.-20It-20was-20discovered-20that-20at-20concentrations-20up-20to-2010 μM,-20BDQ-20inhibited-20H-3Csub-3E2-3C-2Fsub-3EO-3Csub-3E2-3C-2Fsub-3E-20production-20in-20mitochondria.-20BDQ-20(10-2D50 μM)-20suppressed-20the-20opening-20of-20Ca-3Csup-3E2+-3C-2Fsup-3E-2Ddependent-20CsA-2Dsensitive-20mitochondrial-20permeability-20transition-20pore.-20The-20latter-20was-20revealed-20experimentally-20as-20the-20inhibition-20of-20Ca-3Csup-3E2+-3C-2Fsup-3E-2FP-3Csub-3Ei-3C-2Fsub-3E-2Ddependent-20swelling-20of-20mitochondria,-20suppression-20of-20cytochrome-20c-20release,-20and-20an-20increase-20in-20the-20Ca-3Csup-3E2+-3C-2Fsup-3E-20capacity-20of-20the-20organelles.-20BDQ-20also-20decreased-20the-20rate-20of-20mitochondrial-20energy-2Ddependent-20K-3Csup-3E+-3C-2Fsup-3E-20transport,-20which-20was-20evaluated-20by-20the-20energy-2Ddependent-20swelling-20of-20mitochondria-20in-20a-20K-3Csup-3E+-3C-2Fsup-3E-20buffer-20and-20DNP-2Dinduced-20K-3Csup-3E+-3C-2Fsup-3E-20efflux-20from-20the-20organelles.-20The-20possible-20mechanisms-20of-20BDQ-20effect-20of-20rat-20liver-20mitochondria-20are-20discussed." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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