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Property "Has-20abstract" (as page type) with input value "The-20present-20study-20evaluated-20the-20-27-27in-20vivo-27-27-20antitumor-20effects-20and-20toxicity-20of-20a-20new-20Ru(II)-20compound,-20cis-2D(Ru-5Bphen-5D2-5BImH-5D2)-3Csup-3E2+-3C-2Fsup-3E-20(also-20called-20RuphenImH-20-5BRuC-5D),-20against-20Walker-2D256-20carcinosarcoma-20in-20rats.-20After-20subcutaneous-20inoculation-20of-20Walker-2D256-20cells-20in-20the-20right-20pelvic-20limb,-20male-20Wistar-20rats-20received-205-20or-2010mgkg-3Csup-3E-2D1-3C-2Fsup-3E-20RuC-20orally-20or-20intraperitoneally-20(i.p.)-20every-203-20days-20for-2013-20days.-20A-20positive-20control-20group-20(2mgkg-3Csup-3E-2D1-3C-2Fsup-3E-20cisplatin)-20and-20negative-20control-20group-20(vehicle)-20were-20also-20used.-20Tumor-20progression-20was-20checked-20daily.-20After-20treatment,-20tumor-20weight,-20plasma-20biochemistry,-20hematology,-20oxidative-20stress,-20histology,-20and-20tumor-20cell-20respiration-20were-20evaluated.-20RuC-20was-20effective-20against-20tumors-20when-20administered-20i.p.-20but-20not-20orally.-20The-20highest-20i.p.-20dose-20of-20RuC-20(10mgkg-3Csup-3E-2D1-3C-2Fsup-3E)-20significantly-20reduced-20tumor-20volume-20and-20weight,-20induced-20oxidative-20stress-20in-20tumor-20tissue,-20reduced-20the-20respiration-20of-20tumor-20cells,-20and-20induced-20necrosis-20but-20did-20not-20induce-20apoptosis-20in-20the-20tumor.-20No-20clinical-20signs-20of-20toxicity-20or-20death-20were-20observed-20in-20tumor-2Dbearing-20or-20healthy-20rats-20that-20were-20treated-20with-20RuC.-20These-20results-20suggest-20that-20RuC-20has-20antitumor-20activity-20through-20the-20modulation-20of-20oxidative-20stress-20and-20impairment-20of-20oxidative-20phosphorylation,-20thus-20promoting-20Walker-2D256-20cell-20death-20without-20causing-20systemic-20toxicity.-20These-20effects-20make-20RuC-20a-20promising-20anticancer-20drug-20for-20clinical-20evaluation.-0A-0ACopyright-20©-202017-20Elsevier-20Inc.-20All-20rights-20reserved." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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