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This page provides a simple browsing interface for finding entities described by a property and a named value. Other available search interfaces include the page property search, and the ask query builder.

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Property "Has-20abstract" (as page type) with input value "The-20xenotopic-20expression-20of-20the-20alternative-20oxidase-20AOX-20from-20the-20tunicate-20-27-27Ciona-20intestinalis-27-27-20in-20spanerse-20models-20of-20human-20disease-20partially-20alleviates-20the-20phenotypic-20effects-20of-20mitochondrial-20respiratory-20chain-20defects.-20AOX-20is-20a-20non-2Dproton-20pumping,-20mitochondrial-20inner-20membrane-2Dbound,-20single-2Dsubunit-20enzyme-20that-20can-20bypass-20electron-20transport-20through-20the-20cytochrome-20segment,-20providing-20an-20additional-20site-20for-20ubiquinone-20reoxidation-20and-20oxygen-20reduction-20upon-20respiratory-20chain-20overload.-20We-20set-20out-20to-20investigate-20whether-20AOX-20expression-20in-20-27-27Drosophila-27-27-20could-20counteract-20the-20effects-20of-20mitochondrial-20DNA-20(mtDNA)-20replication-20defects-20caused-20by-20disturbances-20in-20the-20mtDNA-20helicase-20or-20DNA-20polymerase-20γ.-20We-20observed-20that-20the-20developmental-20arrest-20imposed-20by-20either-20the-20expression-20of-20mutant-20forms-20of-20these-20enzymes-20or-20their-20knockdown-20was-20not-20rescued-20by-20AOX.-20Considering-20also-20the-20inability-20of-20AOX-20to-20ameliorate-20the-20phenotype-20of-20tko-3Csup-3E25t-3C-2Fsup-3E,-20a-20fly-20mutant-20with-20mitochondrial-20translation-20deficiency,-20we-20infer-20that-20this-20alternative-20enzyme-20may-20not-20be-20applicable-20to-20cases-20of-20mitochondrial-20gene-20expression-20defects.-20Finding-20the-20limitations-20of-20AOX-20applicability-20will-20help-20establish-20the-20parameters-20for-20the-20future-20putative-20use-20of-20this-20enzyme-20in-20gene-20therapies-20for-20human-20mitochondrial-20diseases." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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