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Property "Has-20abstract" (as page type) with input value "Thioacetamide-20(TAA)-20is-20a-20hepatotoxin-20frequently-20used-20for-20experimental-20purposes-20which-20produces-20centrilobular-20necrosis-20after-20a-20single-20dose-20administration.-20In-20spite-20of-20the-20fact-20that-20oxidative-20stress-20seems-20to-20play-20a-20very-20important-20role-20in-20the-20mechanism-20of-20TAA-2Dinduced-20injury,-20the-20effect-20of-20TAA-20on-20hepatocytes-20in-20primary-20culture-20with-20respect-20to-20the-20influence-20on-20mitochondria-20has-20yet-20to-20be-20verified.-20Hepatocytes-20were-20incubated-20for-2024h-20in-20a-20medium-20containing-20TAA-20(0-2D70-20mmol-2Fl).-20Glutathione-20content-20(GSH-2FGSSG),-20reactive-20oxygen-20species-20and-20malondialdehyde-20formation-20were-20assessed-20as-20markers-20of-20cell-20redox-20state.-20Toxicity-20was-20determined-20by-20lactate-20dehydrogenase-20leakage-20and-20WST-2D1-20assay.-20The-20functional-20capacity-20of-20hepatocytes-20was-20evaluated-20from-20albumin-20and-20urea-20production.-20Mitochondrial-20metabolism-20was-20assessed-20by-20measuring-20mitochondrial-20membrane-20potential-20and-20oxygen-20consumption.-20Our-20results-20show-20that-20a-20profound-20decrease-20in-20the-20GSH-20level-20in-20hepatocytes-20precedes-20a-20sharp-20rise-20in-20endogenous-20ROS-20production.-20ROS-20production-20correlates-20with-20an-20increase-20in-20lipoperoxidation.-20Mitochondria-20are-20affected-20by-20TAA-20secondarily-20as-20a-20consequence-20of-20oxidative-20stress.-20Oxidation-20of-20the-20NADH-2Ddependent-20substrates-20of-20respiratory-20Complex-20I-20is-20significantly-20more-20sensitive-20to-20the-20toxic-20action-20of-20TAA-20than-20oxidation-20of-20the-20flavoprotein-2Ddependent-20substrate-20of-20Complex-20II.-20Mitochondria-20can-20also-20maintain-20their-20membrane-20potential-20better-20when-20they-20utilize-20succinate-20as-20a-20respiratory-20substrate.-20It-20appears-20that-20GSH-20should-20be-20depleted-20below-20a-20certain-20critical-20level-20in-20order-20to-20cause-20a-20marked-20increase-20in-20lipid-20peroxidation.-20Mitochondrial-20injury-20can-20then-20occur-20and-20cell-20death-20develops." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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