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Property "Has-20abstract" (as page type) with input value "Tumour-20cells-20are-20characterized-20by-20accelerated-20growth-20usually-20accompanied-20by-20up-2Dregulated-20pathways-20that-20ultimately-20increase-20the-20rate-20of-20ATP-20production.-20These-20cells-20can-20suffer-20metabolic-20reprogramming,-20resulting-20in-20distinct-20bioenergetic-20phenotypes,-20generally-20enhancing-20glycolysis-20channelled-20to-20lactate-20production-20-5B1-5D.-20It-20has-20been-20highlighted-20that-20maintenance-20of-20energy-20homeostasis-20(both-20oxidative-20and-20glycolytic-20metabolism)-20is-20essential-20for-20tumour-20development-20control-20-5B2-5D.-20In-20this-20context-20we-20have-20investigated-20whether-20sodium-20butyrate-20(NaB),-20a-20histone-20deacetylase-20inhibitor,-20alters-20the-20energy-20metabolism-20in-20lung-20cancer-20cells-20(H460)-20and-20if-20these-20effects-20are-20related-20to-20differentiation,-20growth-20arrest-20and-20apoptosis-20observed-20in-20these-20cells-20exposed-20to-2010mM-20NaB-20during-2024-20hours.-20We-20have-20shown-20that-20in-20this-20experimental-20condition,-20cells-20display-20reduced-20glycolytic-20flux-20indicated-20by-20lactate-20production.-20Results-20with-20high-2Dresolution-20respirometry-20show-20increased-20oxidative-20metabolism-20leading-20to-20increased-20rates-20of-20oxygen-20consumption-20coupled-20to-20ATP-20synthesis.-20Mitochondria-20morphology,-20characterized-20by-20electron-20microscopy,-20showed-20increased-20size-20in-20the-20treated-20cells.-20These-20results-20can-20be-20associated-20to-20mitochondrial-20fusion-20because-20we-20have-20detected-20an-20increase-20in-20mitofusin-20mRNA.-20These-20alterations-20on-20the-20energetic-20metabolism-20after-20treatment-20with-20NaB-20suggest-20that-20there-20is-20an-20increase-20in-20mitochondrial-20function-20and-20enhanced-20oxidative-20metabolism.-0A-0A1.-20Kroemer-20G,-20Pouyssegur-20J-20(2008)-20Tumor-20cell-20metabolism:-20cancer's-20Achilles'-20heel.-20Cancer-20Cell-2013:-20472-2D482.-0A-0A2.-20Xu-20WS,-20Parmigiani-20RB,-20Marks-20PA-20(2007)-20Histone-20deacetylase-20inhibitors:-20molecular-20mechanisms-20of-20action.-20Oncogene-2026:-205541-2D5552." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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