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Property "Has-20abstract" (as page type) with input value "We-20show-20that-20the-20cyclin-2Ddependent-20kinase-20inhibitor-201B-20(CDKN1B)-2Fp27,-20previously-20known-20as-20a-20cell-20cycle-20inhibitor,-20is-20also-20localized-20within-20mitochondria.-20The-20migratory-20capacity-20of-20endothelial-20cells,-20which-20need-20intact-20mitochondria,-20is-20completely-20dependent-20on-20mitochondrial-20p27.-20Mitochondrial-20p27-20improves-20mitochondrial-20membrane-20potential,-20increases-20adenosine-20triphosphate-20(ATP)-20content,-20and-20is-20required-20for-20the-20promigratory-20effect-20of-20caffeine.-20Domain-20mapping-20of-20p27-20revealed-20that-20the-20N-2Dterminus-20and-20C-2Dterminus-20are-20required-20for-20those-20improvements.-20Further-20analysis-20of-20those-20regions-20revealed-20that-20the-20translocation-20of-20p27-20into-20the-20mitochondria-20and-20its-20promigratory-20activity-20depend-20on-20serine-2010-20and-20threonine-20187.-20In-20addition,-20mitochondrial-20p27-20protects-20cardiomyocytes-20against-20apoptosis.-20Moreover,-20mitochondrial-20p27-20is-20necessary-20and-20sufficient-20for-20cardiac-20myofibroblast-20differentiation.-20In-20addition,-20p27-20deficiency-20and-20aging-20decrease-20respiration-20in-20heart-20mitochondria.-20Caffeine-20does-20not-20increase-20respiration-20in-20p27-2Ddeficient-20animals,-20whereas-20aged-20mice-20display-20improvement-20after-2010-20days-20of-20caffeine-20in-20drinking-20water.-20Moreover,-20caffeine-20induces-20transcriptome-20changes-20in-20a-20p27-2Ddependent-20manner,-20affecting-20mostly-20genes-20relevant-20for-20mitochondrial-20processes.-20Caffeine-20also-20reduces-20infarct-20size-20after-20myocardial-20infarction-20in-20prediabetic-20mice-20and-20increases-20mitochondrial-20p27.-20Our-20data-20characterize-20mitochondrial-20p27-20as-20a-20common-20denominator-20that-20improves-20mitochondria-2Ddependent-20processes-20and-20define-20an-20increase-20in-20mitochondrial-20p27-20as-20a-20new-20mode-20of-20action-20of-20caffeine." contains invalid characters or is incomplete and therefore can cause unexpected results during a query or annotation process.

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