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Starkov 2010 FEBS J

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Starkov AA (2010) The molecular identity of the mitochondrial Ca2+ sequestration system. FEBS J. 277:3652-63.

ยป PMID: 20659159 Open Access

Starkov AA (2010) FEBS J

Abstract: There is ample evidence to suggest that a dramatic decrease in mitochondrial Ca(2+) retention may contribute to the cell death associated with stroke, excitotoxicity, ischemia and reperfusion, and neurodegenerative diseases. Mitochondria from all studied tissues can accumulate and store Ca(2+) , but the maximum Ca(2+) storage capacity varies widely and exhibits striking tissue specificity. There is currently no explanation for this fact. Precipitation of Ca(2+) and phosphate in the mitochondrial matrix has been suggested to be the major form of storage of accumulated Ca(2+) in mitochondria. How this precipitate is formed is not known. The molecular identity of almost all proteins involved in Ca(2+) transport, storage and formation of the permeability transition pore is also unknown. This review summarizes studies aimed at identifying these proteins, and describes the properties of a known mitochondrial protein that may be involved in Ca(2+) transport and the structure of the permeability transition pore. โ€ข Keywords: Brain mitochondria, Ca2+ accumulation, Ca2+ and Pi precipitate, Calciphorin, Calcium uniporter, Calvectin, Dense granules, gC1qR, Liver mitochondria, Permeability transition pore