Cookies help us deliver our services. By using our services, you agree to our use of cookies. More information

Difference between revisions of "Uncoupler"

From Bioblast
Line 2: Line 2:
|abbr=U
|abbr=U
|description=An '''uncoupler''' is a protonophore ([[CCCP]], [[FCCP]], [[DNP]]) which cycles across the inner mt-membrane with transport of protons and dissipation of the electrochemical proton gradient. Mild uncoupling may be induced at low uncoupler concentrations, the noncoupled state of [[ET-capacity]] is obtained at optimum uncoupler concentration for maximum flux, whereas at higher concentrations an uncoupler-induced inhibition is observed. ย 
|description=An '''uncoupler''' is a protonophore ([[CCCP]], [[FCCP]], [[DNP]]) which cycles across the inner mt-membrane with transport of protons and dissipation of the electrochemical proton gradient. Mild uncoupling may be induced at low uncoupler concentrations, the noncoupled state of [[ET-capacity]] is obtained at optimum uncoupler concentration for maximum flux, whereas at higher concentrations an uncoupler-induced inhibition is observed. ย 
ยป [[#Is_respiration_uncoupled_-_noncoupled_-_dyscoupled.3F |'''MiPNet article''']]
}}
}}
= List of uncouplers =
= List of uncouplers =

Revision as of 16:07, 25 February 2020


high-resolution terminology - matching measurements at high-resolution


Uncoupler

Description

An uncoupler is a protonophore (CCCP, FCCP, DNP) which cycles across the inner mt-membrane with transport of protons and dissipation of the electrochemical proton gradient. Mild uncoupling may be induced at low uncoupler concentrations, the noncoupled state of ET-capacity is obtained at optimum uncoupler concentration for maximum flux, whereas at higher concentrations an uncoupler-induced inhibition is observed.

Abbreviation: U

List of uncouplers

ยป MitoPedia: Uncouplers


Questions.jpg


Click to expand or collaps
Bioblast links: Uncoupling - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>
Specific
ยป Artefacts by single dose uncoupling
ยป ATP synthase
ยป CCCP
ยป Coupling-control protocol
ยป DNP
ยป Dyscoupled respiration
ยป FCCP
ยป Is respiration uncoupled - noncoupled - dyscoupled?
ยป Noncoupled respiration: Discussion
ยป Uncoupler
ยป Uncoupled respiration - see ยป Noncoupled respiration
ยป Uncoupling proteins
ยป Uncoupling protein 1
ยป Uncoupler titrations - Optimum uncoupler concentration
Respiratory states and control ratios
ยป Biochemical coupling efficiency
ยป Coupling-control state
ยป Electron-transfer-pathway state
ยป Electron-transfer pathway
E.jpg ET capacity
ยป E-L coupling efficiency
ยป Flux control efficiency
ยป Flux control ratio
ยป LEAK-control ratio
ยป LEAK respiration
ยป Noncoupled respiration
ยป OXPHOS
ยป OXPHOS capacity; ยป State 3
ยป OXPHOS-control ratio, P/E ratio
ยป Respiratory acceptor control ratio
ยป ROUTINE-control ratio
ยป ROUTINE respiration
ยป ROUTINE state
ยป State 3u
ยป State 4
ยป Uncoupling-control ratio UCR
General (alphabetical order)
ยป Adenine nucleotide translocase
ยป Adenylates
ยป Electron transfer pathway
ยป Mitochondrial preparations
ยป mt-membrane potential
ยป Oxygen flux
ยป Phosphorylation system
ยป Proton leak
ยป Proton slip
ยป TIP2k
Other keyword lists
ยป Template:Keywords: Force and membrane potential



Questions.jpg


Click to expand or collaps
Bioblast links: Force and membrane potential - >>>>>>> - Click on [Expand] or [Collapse] - >>>>>>>
Fundamental relationships
ยป Force
ยป Affinity
ยป Flux
ยป Advancement
ยป Advancement per volume
ยป Stoichiometric number
mt-Membrane potential and protonmotive force
ยป Protonmotive force
ยป Mitochondrial membrane potential
ยป Chemical potential
ยป Faraday constant
ยป Format
ยป Uncoupler
O2k-Potentiometry
ยป O2k-Catalogue: O2k-TPP+ ISE-Module
ยป O2k-Manual: MiPNet15.03 O2k-MultiSensor-ISE
ยป TPP - O2k-Procedures: Tetraphenylphosphonium
ยป Specifications: MiPNet15.08 TPP electrode
ยป Poster
ยป Unspecific binding of TPP+
ยป TPP+ inhibitory effect
O2k-Fluorometry
ยป O2k-Catalogue: O2k-FluoRespirometer
ยป O2k-Manual: MiPNet22.11 O2k-FluoRespirometer manual
ยป Safranin - O2k-Procedures: MiPNet20.13 Safranin mt-membranepotential / Safranin
ยป TMRM - O2k-Procedures: TMRM
O2k-Publications
ยป O2k-Publications: mt-Membrane potential
ยป O2k-Publications: Coupling efficiency;uncoupling


ยปO2k-Publications: Coupling efficiency;uncoupling



MitoPedia topics: Uncoupler 


Labels:




Regulation: Coupling efficiency;uncoupling  Coupling state: LEAK, ET 

HRR: Theory