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::* Knock-out mice for medium chain acyl-CoA dehydrogenase showed impaired enzyme activity on short and medium chain acyl-CoAs.
::* A computer model, similar to the 2013 publication tries to predict the competition model in FAO metabolism. Once again, the model proves itself reliable and correlatable to FAO pathologies.
::* However, it is brought up to light of the importance of the CoASH pool that could play a bigger role than just substrate competition of Acyl-CoAs ennymes.
::* “Here we provide evidence that (1) substrate competition in mFAO – a mechanism inherent to the repetitive metabolism of fatty acids – renders the pathway vulnerable to substrate overload, particularly in the absence of MCAD; (2) this substrate competition is physiologically relevant since it is a key factor in explaining the patientspecific acylcarnitine profiles of MADD patients; and (3) it is clinically relevant since a computational model that included substrate competition was able to explain the severity of the patients’ symptoms from their acylcarnitine profiles, while a similar model without competition could not.”
::* “The resulting flux decline was mediated by a self-amplifying depletion of CoASH.”
::* “CoASH is an essential cofactor, and the maintenance of the CoASH pool is critical for energy metabolism.”
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