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Viruses and mitochondrial medicine

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Revision as of 09:45, 14 March 2020 by Gnaiger Erich (talk | contribs)


high-resolution terminology - matching measurements at high-resolution


Viruses and mitochondrial medicine

Description

Not enough is known about viruses and mitochondrial medicine, although several studies point towards a link between viral infection and mitochondrial dysfunction using high-resolution respirometry, with potential impact on drug development.

Abbreviation: Virus-mt-Medicine

SARS-CoV-2.jpg
Communicated by Gnaiger E 2020-02-23, last update 2020-03-14
Gentle Science
Let's talk COVID-19 - a new culture of communication in science. - Kay Kupferschmidt in Science


News: Coronavirus - COVID-19 or 2019-nCoV

WHO-COVID-19.jpg

»WHO Coronavirus disease (COVID-2019) situation reports«

WHO-COVID-19-dynamics.jpg WHO-COVID-19-dynamics 2.jpg


COVID-19.jpg
2020-03-11 WHO declares COVID-19 a pandemic.



2020-03-10 Corona virus - University of Innsbruck: beginning with March 10, no lectures will take place on the university premises
»https://www.uibk.ac.at/newsroom/information-on-the-corona-virus.html.en«
  • 2019-nCoV (WHO), SARS-CoV-2 (International Committee on Taxonomy of Viruses)
»Previous communications«


Publications: Viruses and mt-medicine

 YearReferenceOrganismTissue;cellStress
Ledur 2020 Sci Rep2020Ledur PF, Karmirian K, Pedrosa CDSG, Souza LRQ, Assis-de-Lemos G, Martins TM, Ferreira JCCG, de Azevedo Reis GF, Silva ES, Silva D, Salerno JA, Ornelas IM, Devalle S, Madeiro da Costa RF, Goto-Silva L, Higa LM, Melo A, Tanuri A, Chimelli L, Murata MM, Garcez PP, Filippi-Chiela EC, Galina A, Borges HL, Rehen SK (2020) Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes. Sci Rep 10:1218.HumanNervous system
Brown 2020 MitoFit Preprint Arch2020Brown RA, Sarkar A (2020) Vitamin D deficiency: a factor in COVID-19, progression, severity and mortality? – An urgent call for research. https://doi.org/10.26124/mitofit:200001Human
Brown 2020 BMJ2020Brown Robert A, Rhein Helga M, Alipio Mark M, Annweiler Cedric, Gnaiger Erich, Holick Michael F, Boucher Barbara J, Duque Gustavo, Féron François, Kenny Rose Anne, Montero-Odasso Manuel, Minisola Salvatore, Rhodes Jonathan, Haq Afrozul, Bejerot Susanne, Reiss Lina AJ, Zgaga Lina, Crawford Michael A, Fricker Rosemary A, Cobbold Peter, Lahore Henry W, Humble Mats B, Sarkar Amrita, Karras Spiros, Iglesias-Gonzalez Javier, Gezen-Ak Duygu, Dursun Erdinc, Cooper Isabella, Grimes David, de Voil Cedric WB (2020) COVID-19 ’ICU’ risk – 20-fold greater in the vitamin D deficient. BAME, African Americans, the older, institutionalised and obese, are at greatest risk. Sun and ‘D’-supplementation – game-changers? Research urgently required. https://doi.org/10.1136/bmj.m1548HumanLung;gill
Fat
Braz-De-Melo 2019 Sci Rep2019Braz-De-Melo HA, Pasquarelli-do-Nascimento G, Corrêa R, das Neves Almeida R, de Oliveira Santos I, Prado PS, Picolo V, de Bem AF, Pizato N, Magalhães KG (2019) Potential neuroprotective and anti-inflammatory effects provided by omega-3 (DHA) against Zika virus infection in human SH-SY5Y cells. Sci Rep 9:20119.HumanNeuroblastoma
Weinstein 2019 bioRxiv2019Weinstein RN, Crawford DL (2019) Effect of EBV-transformation on oxidative phosphorylation physiology in human cell lines. bioRxiv doi: https://doi.org/10.1101/2019.12.16.878025 .HumanOther cell lines
Lymphocyte
Du 2019 J Virol2019Du C, Duan Y, Wang XF, Lin Y, Na L, Wang X, Chen K, Wang X (2019) Attenuation of equine lentivirus alters mitochondrial protein expression profile from inflammation to apoptosis. J Virol 93:e00653-19.HorseBlood cells
Other cell lines
Cell death
Wang 2018 Mol Med Rep2018Wang B, Li W, Fang H, Zhou H (2018) Hepatitis B virus infection is not associated with fatty liver disease: Evidence from a cohort study and functional analysis. Mol Med Rep 19:320-26. https://doi.org/10.3892/mmr.2018.9619HumanLiver
Qu 2018 FASEB J2018Qu C, Zhang S, Wang W, Li M, Wang Y, van der Heijde-Mulder M, Shokrollahi E, Hakim MS, Raat NJH, Peppelenbosch MP, Pan Q (2018) Mitochondrial electron transport chain complex III sustains hepatitis E virus replication and represents an antiviral target. FASEB J 33:1008-19.HumanLiver
Fernandes-Siqueira 2018 mSphere2018Fernandes-Siqueira LO, Zeidler JD, Sousa BG, Ferreira T, Da Poian AT (2018) Anaplerotic role of glucose in the oxidation of endogenous fatty acids during Dengue virus infection. mSphere 3.pii: e00458-17.HumanLiver
Other cell lines
Xia 2016 RSC Adv2016Xia Z, Yi X, Zhuang Y (2016) Stable over-expression of the human malate–aspartate NADH shuttle member Aralar I in PK15 cells improves energy metabolism and enhances proliferation of porcine circovirus-2. RSC Adv 6:61268-77.PigKidney
El-Bacha 2012 Int J Biochem Cell Biol2012El-Bacha T, Da Poian AT (2012) Virus-induced changes in mitochondrial bioenergetics as potential targets for therapy. Int J Biochem Cell Biol 45:41-6.Human
Mouse
Nervous system
Liver
Fibroblast
Oxidative stress;RONS
Morse 2012 J Infect Dis2012Morse CG, Voss JG, Rakocevic G, McLaughlin M, Vinton CL, Huber C, Hu X, Yang J, Huang da W, Logun C, Danner RL, Rangel ZG, Munson PJ, Orenstein JM, Rushing EJ, Lempicki RA, Dalakas MC, Kovacs JA (2012) HIV infection and antiretroviral therapy have divergent effects on mitochondria in adipose tissue. J Infect Dis 205:1778-1787.HumanSkeletal muscle
Blood cells
Fat
Silva 2012 PLOS ONE2012Silva da Costa L, Pereira da Silva AP, Da Poian AT, El-Bacha T (2012) Mitochondrial bioenergetic alterations in mouse neuroblastoma cells infected with Sindbis virus: implications to viral replication and neuronal death. PLoS One 7:e33871.MouseNeuroblastomaMitochondrial disease
Mutuel 2010 Virology2010Mutuel D, Ravallec M, Chabi B, Multeau C, Salmon JM, Fournier P, Ogliastro M (2010) Pathogenesis of Junonia coenia densovirus in Spodoptera frugiperda: a route of infection that leads to hypoxia. Virology 403:137-44.HexapodsIschemia-reperfusion
Oxidative stress;RONS
El-Bacha 2007 Biochim Biophys Acta2007El-Bacha T, Midlej V, Pereira da Silva AP, Silva da Costa L, Benchimol M, Galina A, Da Poian AT (2007) Mitochondrial and bioenergetic dysfunction in human hepatic cells infected with dengue 2 virus. Biochim Biophys Acta 1772:1158-66.HumanLiverCell death
Yuan 2006 Mol Cells2006Yuan X, Shan Y, Yao Z, Li J, Zhao Z, Chen J, Cong Y (2006) Mitochondrial location of severe acute respiratory syndrome coronavirus 3b protein. Mol Cells 21:186–91.HumanCell death
Vrbacky 2003 Physiol Res2003Vrbacký M, Krijt J, Drahota Z, Mĕlková Z (2003) Inhibitory effects of Bcl-2 on mitochondrial respiration. Physiol Res 52:545-54.Human
Other mammals
Endothelial;epithelial;mesothelial cell
Other cell lines
HeLa
Cell death


MitoPedia concepts: MiP concept