Difference between revisions of "Zobi 2012 Dalton Trans"
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|journal=Dalton Trans | |journal=Dalton Trans | ||
|abstract=Cyanocobalamin (B<sub>12</sub>)) offers a biocompatible scaffold for CO-releasing 17-electron dicarbonyl complexes based on the cis-trans-[Re<sup>II</sup>(CO)<sub>2</sub>Br<sub>2</sub>]<sup>0</sup> core. A Co-C≡N-Re conjugate is produced in a short time and high yield from the reaction of [Et<sub>4</sub>N]<sub>2</sub>[Re<sup>II</sup>Br<sub>4</sub>(CO)<sub>2</sub>] (ReCORM-1) with B<sub>12</sub>. The B<sub>12</sub>-Re<sup>II</sup>(CO)<sub>2</sub> derivatives show a number of features which make them pharmaceutically acceptable CO-releasing molecules (CORMs). These cobalamin conjugates are characterized by an improved stability in aqueous aerobic media over the metal complex alone, and afford effective therapeutic protection against ischemia-reperfusion injury in cultured cardiomyocytes. The non-toxicity (at μM concentrations) of the resulting metal fragment after CO release is attributed to the oxidation of the metal and formation in solution of the ReO<sub>4</sub><sup>-</sup> anion, which is among the least toxic of all of the rare inorganic compounds. Theoretical and experimental studies aimed at elucidating the aqueous chemistry of ReCORM-1 are also described. | |abstract=Cyanocobalamin (B<sub>12</sub>)) offers a biocompatible scaffold for CO-releasing 17-electron dicarbonyl complexes based on the cis-trans-[Re<sup>II</sup>(CO)<sub>2</sub>Br<sub>2</sub>]<sup>0</sup> core. A Co-C≡N-Re conjugate is produced in a short time and high yield from the reaction of [Et<sub>4</sub>N]<sub>2</sub>[Re<sup>II</sup>Br<sub>4</sub>(CO)<sub>2</sub>] (ReCORM-1) with B<sub>12</sub>. The B<sub>12</sub>-Re<sup>II</sup>(CO)<sub>2</sub> derivatives show a number of features which make them pharmaceutically acceptable CO-releasing molecules (CORMs). These cobalamin conjugates are characterized by an improved stability in aqueous aerobic media over the metal complex alone, and afford effective therapeutic protection against ischemia-reperfusion injury in cultured cardiomyocytes. The non-toxicity (at μM concentrations) of the resulting metal fragment after CO release is attributed to the oxidation of the metal and formation in solution of the ReO<sub>4</sub><sup>-</sup> anion, which is among the least toxic of all of the rare inorganic compounds. Theoretical and experimental studies aimed at elucidating the aqueous chemistry of ReCORM-1 are also described. | ||
|mipnetlab=CH Zurich Gassmann M, CH Zurich Lundby C | |mipnetlab=CH Zurich Gassmann M, CH Zurich Lundby C, US CO Colorado Springs Jacobs RA | ||
}} | }} | ||
{{Labeling | {{Labeling | ||
|area=Respiration, mt-Medicine, Pharmacology;toxicology | |area=Respiration, mt-Medicine, Pharmacology;toxicology | ||
|injuries=Ischemia-reperfusion | |||
|organism=Rat | |organism=Rat | ||
|tissues=Heart | |tissues=Heart | ||
|preparations=Permeabilized cells | |preparations=Permeabilized cells | ||
|couplingstates=ROUTINE | |couplingstates=ROUTINE | ||
|instruments=Oxygraph-2k | |instruments=Oxygraph-2k | ||
|additional=2016-10 | |additional=2016-10 | ||
}} | }} | ||
Latest revision as of 12:06, 28 March 2018
| Zobi F, Blacque O, Jacobs RA, Schaub MC, Bogdanova AY (2012) 17 e- rhenium dicarbonyl CO-releasing molecules on a cobalamin scaffold for biological application. Dalton Trans 41:370-8. |
Zobi F, Blacque O, Jacobs RA, Schaub MC, Bogdanova AY (2012) Dalton Trans
Abstract: Cyanocobalamin (B12)) offers a biocompatible scaffold for CO-releasing 17-electron dicarbonyl complexes based on the cis-trans-[ReII(CO)2Br2]0 core. A Co-C≡N-Re conjugate is produced in a short time and high yield from the reaction of [Et4N]2[ReIIBr4(CO)2] (ReCORM-1) with B12. The B12-ReII(CO)2 derivatives show a number of features which make them pharmaceutically acceptable CO-releasing molecules (CORMs). These cobalamin conjugates are characterized by an improved stability in aqueous aerobic media over the metal complex alone, and afford effective therapeutic protection against ischemia-reperfusion injury in cultured cardiomyocytes. The non-toxicity (at μM concentrations) of the resulting metal fragment after CO release is attributed to the oxidation of the metal and formation in solution of the ReO4- anion, which is among the least toxic of all of the rare inorganic compounds. Theoretical and experimental studies aimed at elucidating the aqueous chemistry of ReCORM-1 are also described.
• O2k-Network Lab: CH Zurich Gassmann M, CH Zurich Lundby C, US CO Colorado Springs Jacobs RA
Labels: MiParea: Respiration, mt-Medicine, Pharmacology;toxicology
Stress:Ischemia-reperfusion Organism: Rat Tissue;cell: Heart Preparation: Permeabilized cells
Coupling state: ROUTINE
HRR: Oxygraph-2k
2016-10
