Amoedo 2014 Int J Biochem Cell Biol

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Amoedo ND, Rodrigues MF, Rumjanek FD (2014) Mitochondria: are mitochondria accessory to metastasis? Int J Biochem Cell Biol 51: 53-7.

» PMID: 24661997

Amoedo ND, Rodrigues MF, Rumjanek FD (2014) Int J Biochem Cell Biol

Abstract: Since the nineteenth century the importance of mitochondria in cellular physiology has been growing steadily. Not only the organelle harbors the main systems for ATP generation, but also buffers the redox potential in the cytosol and is one of the protagonists of the intrinsic pathway for apoptosis. In tumor cells, mitochondria went from being dysfunctional compartments to playing a supportive or perhaps even a triggering part in metastasis. This "Organelle In Focus" article discusses the classical metabolic events that occur in mitochondria and why these pathways could be essential for the onset of the malignant phenotype. Finally, we propose that the oxidative metabolism of tumor cells in conjunction with the inactivation of anoikis may have been coopted through a non-adaptive evolutionary process.


O2k-Network Lab: BR Rio de Janeiro Rumjanek FD


Labels: MiParea: Respiration  Pathology: Cancer 





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