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Revision as of 10:00, 21 January 2019

MitoPedia: SUIT

Steps and respiratory states

1ce;2ceOmy;3ceU-.jpg

Step State Pathway Q-junction Comment - Events (E) and Marks (M)
ce1 ROUTINE ce1

ROUTINE respiration in the physiological coupling state R. Externally added permeable substrates could contribute to this respiratory state.

ce2Omy L ce1;ce2Omy

Non-phosphorylating resting state (LEAK state); LEAK respiration, Ln, in the presence of oligomycin and absence of ADP, ATP, AMP (no adenylates).


ce3U E ce1;ce2Omy;ce3U

Noncoupled electron transfer state, ET state, with ET capacity E.

ce* ROX ce1;ce2Omy;ce3U;ce*

Rox is the residual oxygen consumption in the ROX state, due to oxidative side reactions, estimated either after inhibition of CIII (e.g. antimycin A, myxothiazol), CIV (e.g. Cyanide) or in the absence of endogenous fuel-substrates. Rox is subtracted from oxygen flux as a baseline for all respiratory states, to obtain mitochondrial respiration.

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